node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0298 | Rv0299 | Rv0298 | Rv0299 | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | 0.989 |
Rv0298 | higB2 | Rv0298 | Rv2022c | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Conserved protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA2. Belongs to the mycobacterial HigB family. | 0.639 |
Rv0298 | higB3 | Rv0298 | Rv3182 | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Conserved hypothetical protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA3. Not toxic upon expression in M.smegmatis. | 0.657 |
Rv0298 | relK | Rv0298 | Rv3358 | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Toxin RelK; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with antitoxin RelJ (shown only for M.smegmatis). Overexpression also increases the number of rifampcin-tolerant persister cells. Belongs to the YoeB family. | 0.748 |
Rv0298 | vapB2 | Rv0298 | Rv0300 | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Possible antitoxin VapB2; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC2. The C-terminal helix of the antitoxin may obstruct the toxin's RNA-binding groove, blocking access to the active sites. Additionally, the C-terminal arginine of the antitoxin may remove Mg(2+) ions from the toxin active sites. | 0.681 |
Rv0298 | vapB48 | Rv0298 | Rv3697A | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Possible antitoxin VapB48; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC48. | 0.800 |
Rv0298 | vapB50 | Rv0298 | Rv3750c | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Possible excisionase; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50. | 0.806 |
Rv0298 | vapC2 | Rv0298 | Rv0301 | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Possible toxin VapC2; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in M.smegmatis inhibits translation, growth and colony formation. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2. | 0.675 |
Rv0298 | vapC45 | Rv0298 | Rv2019 | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Conserved protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB45. | 0.804 |
Rv0298 | vapC50 | Rv0298 | Rv3749c | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB50. | 0.861 |
Rv0299 | Rv0298 | Rv0299 | Rv0298 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. | 0.989 |
Rv0299 | higB2 | Rv0299 | Rv2022c | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Conserved protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA2. Belongs to the mycobacterial HigB family. | 0.552 |
Rv0299 | higB3 | Rv0299 | Rv3182 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Conserved hypothetical protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA3. Not toxic upon expression in M.smegmatis. | 0.651 |
Rv0299 | relK | Rv0299 | Rv3358 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Toxin RelK; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with antitoxin RelJ (shown only for M.smegmatis). Overexpression also increases the number of rifampcin-tolerant persister cells. Belongs to the YoeB family. | 0.657 |
Rv0299 | vapB2 | Rv0299 | Rv0300 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Possible antitoxin VapB2; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC2. The C-terminal helix of the antitoxin may obstruct the toxin's RNA-binding groove, blocking access to the active sites. Additionally, the C-terminal arginine of the antitoxin may remove Mg(2+) ions from the toxin active sites. | 0.781 |
Rv0299 | vapB48 | Rv0299 | Rv3697A | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Possible antitoxin VapB48; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC48. | 0.659 |
Rv0299 | vapB50 | Rv0299 | Rv3750c | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Possible excisionase; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50. | 0.804 |
Rv0299 | vapC2 | Rv0299 | Rv0301 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Possible toxin VapC2; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in M.smegmatis inhibits translation, growth and colony formation. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2. | 0.683 |
Rv0299 | vapC45 | Rv0299 | Rv2019 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Conserved protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB45. | 0.803 |
Rv0299 | vapC50 | Rv0299 | Rv3749c | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. | Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB50. | 0.810 |