node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0457c | mazE1 | Rv0457c | Rv0456B | Probable peptidase; Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. Probable peptidase, similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap). | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.587 |
Rv0457c | mazF1 | Rv0457c | Rv0456A | Probable peptidase; Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. Probable peptidase, similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap). | Possible toxin MazF1; Toxic component of a type II toxin-antitoxin (TA) system, its cognate antitoxin is MazE1 (Probable). Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.589 |
mazE1 | Rv0457c | Rv0456B | Rv0457c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Probable peptidase; Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. Probable peptidase, similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap). | 0.587 |
mazE1 | mazE2 | Rv0456B | Rv0660c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.870 |
mazE1 | mazE3 | Rv0456B | Rv1103c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | 0.658 |
mazE1 | mazE6 | Rv0456B | Rv1991A | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.803 |
mazE1 | mazE8 | Rv0456B | Rv2274A | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE8; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is MazF8. | 0.803 |
mazE1 | mazE9 | Rv0456B | Rv2801A | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | 0.651 |
mazE1 | mazF1 | Rv0456B | Rv0456A | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible toxin MazF1; Toxic component of a type II toxin-antitoxin (TA) system, its cognate antitoxin is MazE1 (Probable). Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.817 |
mazE1 | mazF6 | Rv0456B | Rv1991c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.642 |
mazE1 | vapB27 | Rv0456B | Rv0599c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin VapB27; Antitoxin component of a type II toxin-antitoxin (TA) system. Cognate toxin is VapC27. Upon expression in E.coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9; Belongs to the VapB family. | 0.625 |
mazE1 | vapB40 | Rv0456B | Rv2595 | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin VapB40; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC40. Upon expression in E.coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9; Belongs to the VapB family. | 0.653 |
mazE2 | mazE1 | Rv0660c | Rv0456B | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.870 |
mazE2 | mazE3 | Rv0660c | Rv1103c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | 0.870 |
mazE2 | mazE6 | Rv0660c | Rv1991A | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.803 |
mazE2 | mazE8 | Rv0660c | Rv2274A | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE8; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is MazF8. | 0.870 |
mazE2 | mazF6 | Rv0660c | Rv1991c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.661 |
mazE3 | mazE1 | Rv1103c | Rv0456B | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.658 |
mazE3 | mazE2 | Rv1103c | Rv0660c | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.870 |
mazE3 | mazE6 | Rv1103c | Rv1991A | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.871 |