node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1257c | Rv2280 | Rv1257c | Rv2280 | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | 0.920 |
Rv1257c | aceAa | Rv1257c | Rv1915 | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | 0.903 |
Rv1257c | aceAb | Rv1257c | Rv1916 | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl); Together with AceAa, they could catalyze the formation of succinate and glyoxylate from isocitrate. | 0.903 |
Rv1257c | glcB | Rv1257c | Rv1837c | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA. | 0.918 |
Rv1257c | icl1 | Rv1257c | Rv0467 | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | 0.904 |
Rv2280 | Rv1257c | Rv2280 | Rv1257c | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | 0.920 |
Rv2280 | aceAa | Rv2280 | Rv1915 | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | 0.908 |
Rv2280 | aceAb | Rv2280 | Rv1916 | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl); Together with AceAa, they could catalyze the formation of succinate and glyoxylate from isocitrate. | 0.908 |
Rv2280 | glcB | Rv2280 | Rv1837c | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA. | 0.917 |
Rv2280 | icl1 | Rv2280 | Rv0467 | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | 0.903 |
aceAa | Rv1257c | Rv1915 | Rv1257c | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | 0.903 |
aceAa | Rv2280 | Rv1915 | Rv2280 | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap. | 0.908 |
aceAa | aceAb | Rv1915 | Rv1916 | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl); Together with AceAa, they could catalyze the formation of succinate and glyoxylate from isocitrate. | 0.999 |
aceAa | ackA | Rv1915 | Rv0409 | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Probable acetate kinase AckA (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.666 |
aceAa | acn | Rv1915 | Rv1475c | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase); Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein which binds to selected IRE-like sequences present within the UTRs (untranslated regions) of 3' trxC and 5' IdeR mRNA. Could catalyze the hydration of 2-methyl-ci [...] | 0.917 |
aceAa | glcB | Rv1915 | Rv1837c | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA. | 0.993 |
aceAa | icl1 | Rv1915 | Rv0467 | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | 0.925 |
aceAa | prpC | Rv1915 | Rv1131 | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | 0.485 |
aceAa | ramB | Rv1915 | Rv0465c | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Probable transcriptional regulatory protein; Involved in the control of the glyoxylate cycle. RamB negatively controls the expression of icl expression during growth on acetate as the sole carbon source. Does not regulate the expression of other genes involved in acetate metabolism. Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. | 0.498 |
aceAb | Rv1257c | Rv1916 | Rv1257c | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl); Together with AceAa, they could catalyze the formation of succinate and glyoxylate from isocitrate. | Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. | 0.903 |