node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0575c | Rv0576 | Rv0575c | Rv0576 | Rv0575c, (MTV039.13c), len: 388 aa. Possible oxidoreductase, similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786, E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 salicylate hydroxylase from sphingomonas (395 aa), FASTA scores: opt: 267, E():5e-11,(26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). The transcription of this [...] | Probable transcriptional regulatory protein (possibly ArsR-family); Rv0576, (MTV039.14), len: 434 aa. Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tube [...] | 0.561 |
Rv0575c | TB27.3 | Rv0575c | Rv0577 | Rv0575c, (MTV039.13c), len: 388 aa. Possible oxidoreductase, similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786, E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 salicylate hydroxylase from sphingomonas (395 aa), FASTA scores: opt: 267, E():5e-11,(26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). The transcription of this [...] | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.554 |
Rv0576 | Rv0575c | Rv0576 | Rv0575c | Probable transcriptional regulatory protein (possibly ArsR-family); Rv0576, (MTV039.14), len: 434 aa. Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tube [...] | Rv0575c, (MTV039.13c), len: 388 aa. Possible oxidoreductase, similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786, E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 salicylate hydroxylase from sphingomonas (395 aa), FASTA scores: opt: 267, E():5e-11,(26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). The transcription of this [...] | 0.561 |
Rv0576 | TB27.3 | Rv0576 | Rv0577 | Probable transcriptional regulatory protein (possibly ArsR-family); Rv0576, (MTV039.14), len: 434 aa. Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tube [...] | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.767 |
Rv0887c | TB27.3 | Rv0887c | Rv0577 | Rv0887c, (MTCY31.15c), len: 152 aa. Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 hypothetical protein from Streptomyces coelicolor (194 aa),FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins. | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.653 |
Rv1510 | Rv3349c | Rv1510 | Rv3349c | Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa overlap). | Probable transposase; Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa), FASTA scores: opt: 288, E(): 8.3e-11,(48.5% identity in 97 aa overlap); and others. | 0.815 |
Rv1510 | TB27.3 | Rv1510 | Rv0577 | Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa overlap). | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.810 |
Rv1510 | eccD1 | Rv1510 | Rv3877 | Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa overlap). | ESX-1 secretion system protein EccD1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | 0.787 |
Rv2298 | TB27.3 | Rv2298 | Rv0577 | Conserved protein; Rv2298, (MTCY339.12c), len: 323 aa. Conserved protein. Similar to SLR0545 Synechocystis sp, Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt: 427, E(): 1.7e-20, (39.3% identity in 303 aa overlap) and to YZAE_BACSU P46905 hypothetical protein in natb 3'region (268 aa) FASTA scores, opt: 370, E(): 6.1e-17, (31.4% identity in 264 aa overlap); Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.804 |
Rv3349c | Rv1510 | Rv3349c | Rv1510 | Probable transposase; Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa), FASTA scores: opt: 288, E(): 8.3e-11,(48.5% identity in 97 aa overlap); and others. | Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa overlap). | 0.815 |
Rv3349c | TB27.3 | Rv3349c | Rv0577 | Probable transposase; Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa), FASTA scores: opt: 288, E(): 8.3e-11,(48.5% identity in 97 aa overlap); and others. | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.674 |
Rv3349c | eccD1 | Rv3349c | Rv3877 | Probable transposase; Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa), FASTA scores: opt: 288, E(): 8.3e-11,(48.5% identity in 97 aa overlap); and others. | ESX-1 secretion system protein EccD1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | 0.621 |
Rv3369 | TB27.3 | Rv3369 | Rv0577 | Conserved protein; Rv3369, (MTV004.27), len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa),FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap). | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | 0.510 |
TB27.3 | Rv0575c | Rv0577 | Rv0575c | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Rv0575c, (MTV039.13c), len: 388 aa. Possible oxidoreductase, similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786, E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 salicylate hydroxylase from sphingomonas (395 aa), FASTA scores: opt: 267, E():5e-11,(26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). The transcription of this [...] | 0.554 |
TB27.3 | Rv0576 | Rv0577 | Rv0576 | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Probable transcriptional regulatory protein (possibly ArsR-family); Rv0576, (MTV039.14), len: 434 aa. Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tube [...] | 0.767 |
TB27.3 | Rv0887c | Rv0577 | Rv0887c | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Rv0887c, (MTCY31.15c), len: 152 aa. Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 hypothetical protein from Streptomyces coelicolor (194 aa),FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins. | 0.653 |
TB27.3 | Rv1510 | Rv0577 | Rv1510 | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa overlap). | 0.810 |
TB27.3 | Rv2298 | Rv0577 | Rv2298 | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Conserved protein; Rv2298, (MTCY339.12c), len: 323 aa. Conserved protein. Similar to SLR0545 Synechocystis sp, Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt: 427, E(): 1.7e-20, (39.3% identity in 303 aa overlap) and to YZAE_BACSU P46905 hypothetical protein in natb 3'region (268 aa) FASTA scores, opt: 370, E(): 6.1e-17, (31.4% identity in 264 aa overlap); Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | 0.804 |
TB27.3 | Rv3349c | Rv0577 | Rv3349c | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Probable transposase; Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa), FASTA scores: opt: 288, E(): 8.3e-11,(48.5% identity in 97 aa overlap); and others. | 0.674 |
TB27.3 | Rv3369 | Rv0577 | Rv3369 | Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL- 12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses. | Conserved protein; Rv3369, (MTV004.27), len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa),FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap). | 0.510 |