STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vapC7Possible toxin VapC7; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB7 (By similarity). Belongs to the PINc/VapC protein family. (145 aa)    
Predicted Functional Partners:
vapB7
Possible antitoxin VapB7; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC7.
  
  
 0.942
vapB43
Possible antitoxin VapB43; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC43.
   
 
 0.798
vapC43
Possible toxin VapC43. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB43.; Belongs to the PINc/VapC protein family.
   
  
 0.762
vapB8
Possible antitoxin VapB8; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC8.
  
  
 0.736
vapC9
Possible toxin VapC9; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB9 (By similarity). Belongs to the PINc/VapC protein family.
      
 0.697
vapC32
Possible toxin VapC32. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB32.; Belongs to the PINc/VapC protein family.
  
  
 0.628
vapB10
Possible antitoxin VapB10; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC10.
      
 0.603
mazE2
Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system.
  
    0.561
vapC23
Possible toxin VapC23; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB23 (By similarity). Belongs to the PINc/VapC protein family.
   
  
 0.544
atsD
Rv0663, (MTCI376.13c), len: 787 aa. Possible atsD,arylsulfatase, similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity in 544 aa overlap); etc. Also similar to P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium tuberculosis (787 aa), FASTA score: (38.9% identity in 769 aa overlap); and other arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa), Rv0711, etc. Contains PS00523 Sulfatases signature 1. Belongs to the sulfatase family. This region is a possible MT-complex-specif [...]
  
    0.542
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.