node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1049 | mmpL5 | Rv1049 | Rv0676c | Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn-helix motif at aa 58-79 (Score 1495, +4.28 SD). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | 0.808 |
Rv1049 | mmpR5 | Rv1049 | Rv0678 | Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn-helix motif at aa 58-79 (Score 1495, +4.28 SD). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions. | 0.811 |
Rv1049 | mmpS5 | Rv1049 | Rv0677c | Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn-helix motif at aa 58-79 (Score 1495, +4.28 SD). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Possible conserved membrane protein MmpS5; Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence. Belongs to the MmpS family. | 0.699 |
Rv1049 | pepQ | Rv1049 | Rv2535c | Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn-helix motif at aa 58-79 (Score 1495, +4.28 SD). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Rv2535c, (MTCY159.21), len: 372 aa. Probable pepQ,cytoplasmic peptidase, equivalent to Q9CCS1|PEPQ|ML0521 putative cytoplasmic peptidase from Mycobacterium leprae (376 aa), FASTA scores: opt: 1954, E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU putative peptidase (belongs to peptidase family M24B) from Bacillus subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c putative peptidase from Streptomyces coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39, (43.15% iden [...] | 0.447 |
Rv1598c | eccD3 | Rv1598c | Rv0290 | Conserved protein; Rv1598c, (MTCY336.06), len: 136 aa. Conserved protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa). | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.709 |
Rv1598c | mmpL5 | Rv1598c | Rv0676c | Conserved protein; Rv1598c, (MTCY336.06), len: 136 aa. Conserved protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa). | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | 0.724 |
Rv3160c | mmpL5 | Rv3160c | Rv0676c | Rv3160c, (MTV014.04c), len: 213 aa. Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR protein (global repressor in the nitrogen regulation system; see Jakoby et al., 2000) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c putative regulatory protein from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c putative transcriptional regulator from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173, E(): 0.00027, (27.25% id [...] | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | 0.799 |
Rv3160c | mmpR5 | Rv3160c | Rv0678 | Rv3160c, (MTV014.04c), len: 213 aa. Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR protein (global repressor in the nitrogen regulation system; see Jakoby et al., 2000) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c putative regulatory protein from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c putative transcriptional regulator from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173, E(): 0.00027, (27.25% id [...] | Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions. | 0.799 |
atpE | mmpL5 | Rv1305 | Rv0676c | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | 0.909 |
atpE | mmpR5 | Rv1305 | Rv0678 | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions. | 0.870 |
atpE | mmpS5 | Rv1305 | Rv0677c | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Possible conserved membrane protein MmpS5; Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence. Belongs to the MmpS family. | 0.828 |
atpE | pepQ | Rv1305 | Rv2535c | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Rv2535c, (MTCY159.21), len: 372 aa. Probable pepQ,cytoplasmic peptidase, equivalent to Q9CCS1|PEPQ|ML0521 putative cytoplasmic peptidase from Mycobacterium leprae (376 aa), FASTA scores: opt: 1954, E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU putative peptidase (belongs to peptidase family M24B) from Bacillus subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c putative peptidase from Streptomyces coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39, (43.15% iden [...] | 0.968 |
eccD3 | Rv1598c | Rv0290 | Rv1598c | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | Conserved protein; Rv1598c, (MTCY336.06), len: 136 aa. Conserved protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa). | 0.709 |
eccD3 | lppX | Rv0290 | Rv2945c | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | 0.506 |
eccD3 | mmpL5 | Rv0290 | Rv0676c | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | 0.745 |
lppX | eccD3 | Rv2945c | Rv0290 | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.506 |
lppX | mmpL5 | Rv2945c | Rv0676c | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | 0.672 |
mmpL5 | Rv1049 | Rv0676c | Rv1049 | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn-helix motif at aa 58-79 (Score 1495, +4.28 SD). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.808 |
mmpL5 | Rv1598c | Rv0676c | Rv1598c | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | Conserved protein; Rv1598c, (MTCY336.06), len: 136 aa. Conserved protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa). | 0.724 |
mmpL5 | Rv3160c | Rv0676c | Rv3160c | Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores. | Rv3160c, (MTV014.04c), len: 213 aa. Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR protein (global repressor in the nitrogen regulation system; see Jakoby et al., 2000) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c putative regulatory protein from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c putative transcriptional regulator from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173, E(): 0.00027, (27.25% id [...] | 0.799 |