Probable low-affinity inorganic phosphate transporter integral membrane protein PitA; Low-affinity inorganic phosphate transport.

Probable transcriptional regulatory protein EmbR; Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities; Belongs to the AfsR/DnrI/RedD regulatory family.

Two component sensor histidine kinase DevS; Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. Required for full induction of the DevR (DosR) regulon; acts later than DosT to positively regulate expression of the DevR regulon during adaptation to anaerobiosis. Characterized as an oxygen sensor; O(2) acts as a switch, with O(2)-bound Fe(2+) protein inactive in autophosphorylation. Has also been suggested to act as a redox sensor, or perhaps as a dual oxygen/redox sensor. Autophosph [...]

Rv3331, (MTV016.31), len: 502 aa (start uncertain). Probable sugI, sugar-transport integral membrane protein,possibly member of major facilitator superfamily (MFS),similar to several transporters e.g. P37021|GALP_ECOLI|B2943 galactose-proton symporter (galactose transporter) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39, (31.85% identity in 446 aa overlap); P96742|YWTG metabolite-transport-related protein from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39, (33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) galac [...]

Rv0915c, (MTCY21C12.09c), len: 423 aa. PPE14 (alternate gene name: MTB41). Member of the Mycobacterium tuberculosis PPE family (see citation below), highly similar to many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa), FASTA scores: opt: 966, E(): 4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.

Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases.

Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...]

Possible two component sensor kinase; Member of the two-component regulatory system NarS/NarL involved in gene expression during aerobic nitrate metabolism. Plays therefore a crucial role in anaerobic survival of mycobacteria in host. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of NarL. In turn, NarL binds to the upstream promoter regions of target genes to regulate their expression during aerobic nitrate metabolism.

Probable citrate synthase II CitA; Rv0889c, (MTCY31.17c), len: 373 aa. Probable citA (alternate gene name: gltA), citrate synthase 2, highly similar to others e.g. CAB95899.1|AL359988 putative citrate synthase from Streptomyces coelicolor (387 aa); P39119|CISY_BACSU citrate synthase II from Bacillus subtilis (366 aa), FASTA scores: opt: 586, E(): 5.8e-30,(33.8% identity in 367 aa overlap); etc. Also similar to Rv0896|MTCY31.24 from Mycobacterium tuberculosis (29.2% identity in 274 aa overlap) and Rv1131. Contains PS00480 Citrate synthase signature. Belongs to the citrate synthase family.