STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arfCPossible conserved exported or membrane protein; Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Belongs to the ArfC membrane protein family. (175 aa)    
Predicted Functional Partners:
ompA
Outer membrane protein A OmpA; Probably plays a role in ammonia secretion that neutralizes the medium at pH 5.5, although it does not play a direct role in ammonia transport. The OmpA-like domain (196-326) binds M.tuberculosis peptidoglycan. Overexpression in M.bovis or M.smegmatis gives channels with average conductance value of 1,600 +/- 100 pS, but this may not be physiologically relevant; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. ArfA family.
 
  
 0.986
arfB
Possible membrane protein; Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Belongs to the ArfB membrane protein family.
  
  
 0.984
Rv3412
Rv3412, (MTCY78.16c), len: 136 aa. Hypothetical protein, strongly similar to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 hypothetical 15.3 KDA protein from Mycobacterium leprae (137 aa), FASTA scores: opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004); To M.leprae ML0386.
   
  
 0.862
PE_PGRS13
PE-PGRS family protein PE_PGRS13; Rv0833, (MTV043.25), len: 749 aa. PE_PGRS13, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 2002), but lacking N-terminal domain (present in preceding ORF),possibly due to frameshift. Similar in part to many others e.g. MTCY28_25|Z95890 (914 aa), FASTA scores: opt: 2726,E(): 0, (60.1% identity in 776 aa overlap); etc.
      
 0.695
espK
ESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1.
  
     0.654
ask
Aspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha); Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family.
   
  
 0.632
PPE65
PPE family protein PPE65; Rv3621c, (MTCY15C10.31, MTCY07H7B.01), len: 413 aa. PPE65, Member of the Mycobacterium tuberculosis PPE family,ala-, gly-rich proteins, similar to many e.g. Q10813|YS92_MYCTU|Rv2892c|MT2959|MTCY274.23c (408 aa) FASTA scores: opt: 955, E(): 1.8e-42, (44.45% identity in 423 aa overlap).
   
  
 0.620
PE_PGRS30
PE-PGRS family protein PE_PGRS30; Mediates suppression of proinflammatory immune response in macrophages via modulation of host cytokine response. Required for full virulence. Involved in inhibition of phago-lysosome fusion.
  
     0.610
Rv0898c
Rv0898c, (MTCY31.26c), len: 87 aa. Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap).
       0.605
PE_PGRS16
PE-PGRS family protein PE_PGRS16; Rv0977, (MTV044.05), len: 923 aa. PE_PGRS16, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (51.5% identity in 750 aa overlap); etc.
  
     0.577
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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