node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
lpqH | lprA | Rv3763 | Rv1270c | 19 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family. | Possible lipoprotein LprA; Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages. Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs). Does not induce murine macrophage apoptosis or necrosis. Non- acylated protein does not act as a TLR2 agonist. Requires only host TLR2 as receptors to eli [...] | 0.955 |
lpqH | pstS1 | Rv3763 | Rv0934 | 19 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family. | Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). | 0.867 |
lpqH | pstS2 | Rv3763 | Rv0932c | 19 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family. | Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). | 0.607 |
lpqH | pstS3 | Rv3763 | Rv0928 | 19 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family. | Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1); Functions in inorganic phosphate uptake, is probably the main carrier for phosphate uptake, it is the most highly expressed of the 3 PstS proteins under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Probably plays a role in host phagosome maturation arrest. | 0.652 |
lprA | lpqH | Rv1270c | Rv3763 | Possible lipoprotein LprA; Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages. Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs). Does not induce murine macrophage apoptosis or necrosis. Non- acylated protein does not act as a TLR2 agonist. Requires only host TLR2 as receptors to eli [...] | 19 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family. | 0.955 |
lprA | pstS1 | Rv1270c | Rv0934 | Possible lipoprotein LprA; Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages. Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs). Does not induce murine macrophage apoptosis or necrosis. Non- acylated protein does not act as a TLR2 agonist. Requires only host TLR2 as receptors to eli [...] | Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). | 0.901 |
lprA | pstS2 | Rv1270c | Rv0932c | Possible lipoprotein LprA; Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages. Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs). Does not induce murine macrophage apoptosis or necrosis. Non- acylated protein does not act as a TLR2 agonist. Requires only host TLR2 as receptors to eli [...] | Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). | 0.785 |
lprA | pstS3 | Rv1270c | Rv0928 | Possible lipoprotein LprA; Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages. Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs). Does not induce murine macrophage apoptosis or necrosis. Non- acylated protein does not act as a TLR2 agonist. Requires only host TLR2 as receptors to eli [...] | Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1); Functions in inorganic phosphate uptake, is probably the main carrier for phosphate uptake, it is the most highly expressed of the 3 PstS proteins under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Probably plays a role in host phagosome maturation arrest. | 0.565 |
phoT | pstA1 | Rv0820 | Rv0930 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Probable phosphate-transport integral membrane ABC transporter PstA1; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.994 |
phoT | pstA2 | Rv0820 | Rv0936 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Phosphate-transport integral membrane ABC transporter PstA2; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.990 |
phoT | pstB | Rv0820 | Rv0933 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Phosphate-transport ATP-binding protein ABC transporter PstB; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | 0.908 |
phoT | pstC1 | Rv0820 | Rv0935 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Phosphate-transport integral membrane ABC transporter PstC1; Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.988 |
phoT | pstC2 | Rv0820 | Rv0929 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Phosphate-transport integral membrane ABC transporter PstC2; Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.994 |
phoT | pstS1 | Rv0820 | Rv0934 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). | 0.971 |
phoT | pstS2 | Rv0820 | Rv0932c | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). | 0.973 |
phoT | pstS3 | Rv0820 | Rv0928 | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1); Functions in inorganic phosphate uptake, is probably the main carrier for phosphate uptake, it is the most highly expressed of the 3 PstS proteins under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Probably plays a role in host phagosome maturation arrest. | 0.982 |
pstA1 | phoT | Rv0930 | Rv0820 | Probable phosphate-transport integral membrane ABC transporter PstA1; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | 0.994 |
pstA1 | pstA2 | Rv0930 | Rv0936 | Probable phosphate-transport integral membrane ABC transporter PstA1; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | Phosphate-transport integral membrane ABC transporter PstA2; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.936 |
pstA1 | pstB | Rv0930 | Rv0933 | Probable phosphate-transport integral membrane ABC transporter PstA1; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | Phosphate-transport ATP-binding protein ABC transporter PstB; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. | 0.993 |
pstA1 | pstC1 | Rv0930 | Rv0935 | Probable phosphate-transport integral membrane ABC transporter PstA1; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | Phosphate-transport integral membrane ABC transporter PstC1; Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.994 |