node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0968 | Rv0970 | Rv0968 | Rv0970 | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | 0.973 |
Rv0968 | Rv2963 | Rv0968 | Rv2963 | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | 0.460 |
Rv0968 | csoR | Rv0968 | Rv0967 | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Copper-sensitive operon repressor CsoR; Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region. | 0.968 |
Rv0968 | ctpV | Rv0968 | Rv0969 | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Probable metal cation transporter P-type ATPase CtpV; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence. | 0.985 |
Rv0968 | lpqS | Rv0968 | Rv0847 | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | 0.429 |
Rv0968 | mmcO | Rv0968 | Rv0846c | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Probable oxidase; Required for copper resistance. In vitro, oxidizes organic substrates and Fe(2+). May act in vivo by oxidation of toxic periplasmic Cu(+); Belongs to the multicopper oxidase family. | 0.547 |
Rv0968 | mymT | Rv0968 | Rv0186A | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | 0.431 |
Rv0968 | ricR | Rv0968 | Rv0190 | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection. | 0.440 |
Rv0970 | Rv0968 | Rv0970 | Rv0968 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | 0.973 |
Rv0970 | Rv0988 | Rv0970 | Rv0988 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Rv0988, (MTCI237.02), len: 386 aa. Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH protein from Agrobacterium tumefaciens (355 aa), FASTA scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa overlap); and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa). Predicted to be an outer membrane protein (See Song et al., 2008). Believed to have been acquired by horizontal gene transfer (See Rosas-Magallanes et el., 2006; Becq et al., 2007). | 0.435 |
Rv0970 | Rv2963 | Rv0970 | Rv2963 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | 0.437 |
Rv0970 | csoR | Rv0970 | Rv0967 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Copper-sensitive operon repressor CsoR; Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region. | 0.940 |
Rv0970 | ctpA | Rv0970 | Rv0092 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.451 |
Rv0970 | ctpV | Rv0970 | Rv0969 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Probable metal cation transporter P-type ATPase CtpV; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence. | 0.961 |
Rv0970 | lpqS | Rv0970 | Rv0847 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | 0.418 |
Rv0970 | mmcO | Rv0970 | Rv0846c | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Probable oxidase; Required for copper resistance. In vitro, oxidizes organic substrates and Fe(2+). May act in vivo by oxidation of toxic periplasmic Cu(+); Belongs to the multicopper oxidase family. | 0.633 |
Rv0970 | mymT | Rv0970 | Rv0186A | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | 0.510 |
Rv0970 | ricR | Rv0970 | Rv0190 | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection. | 0.451 |
Rv0988 | Rv0970 | Rv0988 | Rv0970 | Rv0988, (MTCI237.02), len: 386 aa. Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH protein from Agrobacterium tumefaciens (355 aa), FASTA scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa overlap); and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa). Predicted to be an outer membrane protein (See Song et al., 2008). Believed to have been acquired by horizontal gene transfer (See Rosas-Magallanes et el., 2006; Becq et al., 2007). | Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa). | 0.435 |
Rv2963 | Rv0968 | Rv2963 | Rv0968 | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa). | 0.460 |