node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3230c | desA1 | Rv3230c | Rv0824c | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.931 |
Rv3230c | desA2 | Rv3230c | Rv1094 | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.930 |
Rv3230c | desA3 | Rv3230c | Rv3229c | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.999 |
Rv3230c | fas | Rv3230c | Rv2524c | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Rv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa. Probable fas, Fatty Acid Synthase, equivalent to Q9X7E2|fas|ML1191 putative type I fatty acid synthase from Mycobacterium leprae (3076 aa), FASTA scores: opt: 17484,E(): 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|fas|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa), FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|fas from Mycobacterium bovis (2796 aa),FASTA scores: opt: 2098, E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see Fernande [...] | 0.569 |
desA1 | Rv3230c | Rv0824c | Rv3230c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | 0.931 |
desA1 | desA2 | Rv0824c | Rv1094 | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.989 |
desA1 | desA3 | Rv0824c | Rv3229c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.974 |
desA1 | dus | Rv0824c | Rv0823c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Possible transcriptional regulatory protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. | 0.979 |
desA1 | fas | Rv0824c | Rv2524c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Rv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa. Probable fas, Fatty Acid Synthase, equivalent to Q9X7E2|fas|ML1191 putative type I fatty acid synthase from Mycobacterium leprae (3076 aa), FASTA scores: opt: 17484,E(): 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|fas|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa), FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|fas from Mycobacterium bovis (2796 aa),FASTA scores: opt: 2098, E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see Fernande [...] | 0.931 |
desA1 | fdxC | Rv0824c | Rv1177 | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Probable ferredoxin FdxC; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.896 |
desA1 | nrdE | Rv0824c | Rv3051c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. When coexpressed in E.coli with nrdF2 the 2 proteins complement a temperature-sensitive E.coli mutant, however coexpression with nrdF1 does not complement. Belongs to the ribonucleoside diphosphate reductase large chain family. | 0.772 |
desA1 | nrdI | Rv0824c | Rv3052c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Probable NrdI protein; Probably involved in ribonucleotide reductase function. | 0.845 |
desA1 | nrdZ | Rv0824c | Rv0570 | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.769 |
desA1 | phoH2 | Rv0824c | Rv1095 | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Rv1095, (MTV017.48), len: 433 aa. Probable phoH2,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity in 432 aa overlap). Similar to many proteins described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444 aa overlap); or Mycobacterium tuberculosis Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in 241 aa overlap). Contains PS00017 ATP/G [...] | 0.504 |
desA2 | Rv3230c | Rv1094 | Rv3230c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | 0.930 |
desA2 | desA1 | Rv1094 | Rv0824c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.989 |
desA2 | desA3 | Rv1094 | Rv3229c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.987 |
desA2 | dus | Rv1094 | Rv0823c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Possible transcriptional regulatory protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. | 0.874 |
desA2 | fas | Rv1094 | Rv2524c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Rv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa. Probable fas, Fatty Acid Synthase, equivalent to Q9X7E2|fas|ML1191 putative type I fatty acid synthase from Mycobacterium leprae (3076 aa), FASTA scores: opt: 17484,E(): 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|fas|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa), FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|fas from Mycobacterium bovis (2796 aa),FASTA scores: opt: 2098, E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see Fernande [...] | 0.931 |
desA2 | fdxC | Rv1094 | Rv1177 | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Probable ferredoxin FdxC; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.883 |