Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rv0332 | prpR | Rv0332 | Rv1129c | Conserved protein; Rv0332, (MTCY63.37), len: 261 aa. Conserved protein,similar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% identity in 251 aa overlap). | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.506 |
| Rv0366c | prpR | Rv0366c | Rv1129c | Rv0366c, (MTV036.01c), len: 197 aa. Conserved hypothetical protein, showing weak similarity to HI1395|P44173|YD95_HAEIN hypothetical protein from Haemophilus influenzae (140 aa), FASTA scores: opt: 152,E(): 0.0015, (27.0% identity in 126 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 Glycine radical signature. | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.473 |
| Rv1128c | prpC | Rv1128c | Rv1131 | Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc; Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family. | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | 0.414 |
| Rv1128c | prpD | Rv1128c | Rv1130 | Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc; Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family. | Possible methylcitrate dehydratase PrpD; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity). | 0.413 |
| Rv1128c | prpR | Rv1128c | Rv1129c | Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc; Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family. | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.549 |
| Rv1132 | prpC | Rv1132 | Rv1131 | Conserved membrane protein; Rv1132, (MTCY22G8.21), len: 576 aa. Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa),fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap). | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | 0.852 |
| Rv1132 | prpD | Rv1132 | Rv1130 | Conserved membrane protein; Rv1132, (MTCY22G8.21), len: 576 aa. Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa),fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap). | Possible methylcitrate dehydratase PrpD; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity). | 0.788 |
| Rv1132 | prpR | Rv1132 | Rv1129c | Conserved membrane protein; Rv1132, (MTCY22G8.21), len: 576 aa. Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa),fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap). | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.606 |
| Rv3833 | prpR | Rv3833 | Rv1129c | Transcriptional regulatory protein (probably AraC-family); Rv3833, (MTCY01A6.36c), len: 263 aa. Probable transcriptional regulator belonging to araC family, similar to others e.g. Q9KYN4|SC9H11.05 putative AraC-family transcriptional regulator from Streptomyces coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42, (50.45% identity in 232 aa overlap); Q9HXH2|PA3830 probable transcriptional regulator from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26, (34.85% identity in 238 aa overlap); Q9HX87|PA3927 probable transcriptional regulator from Pseudomonas aerugi [...] | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.455 |
| icl1 | prpC | Rv0467 | Rv1131 | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | 0.894 |
| icl1 | prpD | Rv0467 | Rv1130 | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | Possible methylcitrate dehydratase PrpD; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity). | 0.772 |
| icl1 | prpR | Rv0467 | Rv1129c | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.755 |
| mutB | prpC | Rv1493 | Rv1131 | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | 0.853 |
| mutB | prpD | Rv1493 | Rv1130 | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | Possible methylcitrate dehydratase PrpD; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity). | 0.447 |
| mutB | prpR | Rv1493 | Rv1129c | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | Probable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA [...] | 0.413 |
| prpC | Rv1128c | Rv1131 | Rv1128c | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc; Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family. | 0.414 |
| prpC | Rv1132 | Rv1131 | Rv1132 | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | Conserved membrane protein; Rv1132, (MTCY22G8.21), len: 576 aa. Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa),fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap). | 0.852 |
| prpC | icl1 | Rv1131 | Rv0467 | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | 0.894 |
| prpC | mutB | Rv1131 | Rv1493 | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | 0.853 |
| prpC | prpD | Rv1131 | Rv1130 | Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. | Possible methylcitrate dehydratase PrpD; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity). | 0.999 |
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