node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1191 | Rv1192 | Rv1191 | Rv1192 | Conserved protein; Rv1191, (MTCI364.03), len: 304 aa. Conserved protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (310 aa), FASTA scores: opt: 196, E(): 1.3e-05, (32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature. | Unknown protein; Rv1192, (MTCI364.04), len: 275 aa. Unknown protein,contains PS00120 lipases, serine active site. | 0.784 |
Rv1191 | fadD36 | Rv1191 | Rv1193 | Conserved protein; Rv1191, (MTCI364.03), len: 304 aa. Conserved protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (310 aa), FASTA scores: opt: 196, E(): 1.3e-05, (32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature. | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | 0.778 |
Rv1192 | Rv1191 | Rv1192 | Rv1191 | Unknown protein; Rv1192, (MTCI364.04), len: 275 aa. Unknown protein,contains PS00120 lipases, serine active site. | Conserved protein; Rv1191, (MTCI364.03), len: 304 aa. Conserved protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (310 aa), FASTA scores: opt: 196, E(): 1.3e-05, (32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature. | 0.784 |
Rv1192 | fadD36 | Rv1192 | Rv1193 | Unknown protein; Rv1192, (MTCI364.04), len: 275 aa. Unknown protein,contains PS00120 lipases, serine active site. | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | 0.847 |
echA9 | fadD36 | Rv1071c | Rv1193 | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | 0.909 |
echA9 | fadE25 | Rv1071c | Rv3274c | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Rv3274c, (MTCY71.14c), len: 389 aa. Probable fadE25,Acyl-CoA Dehydrogenase, equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 probable acyl-CoA dehydrogenase FADE25 from Mycobacterium leprae (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|fade fatty acid acyl-CoA dehydrogenase from Streptomyces lividans (385 aa), FASTA scores: opt: 1692,E(): 4.9e-99, (67.35% identity in 383 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in 376 a [...] | 0.945 |
echA9 | fadE32 | Rv1071c | Rv3563 | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Rv3563, (MTCY06G11.10), len: 319 aa. Probable fadE32, acyl-CoA dehydrogenase, similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285, E(): 4.1e-10,(30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 230,E(): 1.1e-07, (25.5% identity in [...] | 0.952 |
echA9 | fadE33 | Rv1071c | Rv3564 | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Rv3564, (MTCY06G11.11), len: 318 aa. Probable fadE33, acyl-CoA dehydrogenase, similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity in 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95% identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from Streptomyces coelicolor (395 aa), FASTA scores: opt: 273, E(): 2.5e-09,(30.1% identity in 352 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 478,E(): 7.9e-22, (32.9% identity [...] | 0.916 |
echA9 | fadE34 | Rv1071c | Rv3573c | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Probable acyl-CoA dehydrogenase FadE34; Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the highly specific dehydrogenation of acyl-CoA ester side chains of 3- oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24- oyl-CoA. | 0.919 |
echA9 | fadE5 | Rv1071c | Rv0244c | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Rv0244c, (MTV034.10c), len: 611 aa. Probable fadE5,acyl-CoA dehydrogenase, equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa), FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa), FASTA scores: opt: 2576, E(): 0,(64.6% identity in 611 aa overlap); and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229, E(): 6.8e-08,(29.8% identity in 409 aa overlap); etc. | 0.851 |
echA9 | ltp2 | Rv1071c | Rv3540c | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | Rv3540c, (MTCY03C7.16), len: 386 aa. Probable ltp2,lipid-transfer protein or keto acyl-CoA thiolase, similar to several e.g. Q9X4X2|DITF DITF protein (hypothetical protein, similar to non-specific lipid-transfer protein and 3-ketoacyl-CoA thiolase) from Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, E(): 5.3e-34, (33.4% identity in 392 aa overlap); O30255|AF2416 3-ketoacyl-CoA thiolase (ACAB-12) from Archaeoglobus fulgidus (384 aa),FASTA scores: opt: 496, E(): 1.6e-23, (30.35% identity in 389 aa overlap); O28978|AF1291 3-ketoacyl-CoA thiolase (ACAB-11) from Archaeoglobus f [...] | 0.910 |
fadD36 | Rv1191 | Rv1193 | Rv1191 | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Conserved protein; Rv1191, (MTCI364.03), len: 304 aa. Conserved protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (310 aa), FASTA scores: opt: 196, E(): 1.3e-05, (32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature. | 0.778 |
fadD36 | Rv1192 | Rv1193 | Rv1192 | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Unknown protein; Rv1192, (MTCI364.04), len: 275 aa. Unknown protein,contains PS00120 lipases, serine active site. | 0.847 |
fadD36 | echA9 | Rv1193 | Rv1071c | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulo [...] | 0.909 |
fadD36 | fadE25 | Rv1193 | Rv3274c | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Rv3274c, (MTCY71.14c), len: 389 aa. Probable fadE25,Acyl-CoA Dehydrogenase, equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 probable acyl-CoA dehydrogenase FADE25 from Mycobacterium leprae (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|fade fatty acid acyl-CoA dehydrogenase from Streptomyces lividans (385 aa), FASTA scores: opt: 1692,E(): 4.9e-99, (67.35% identity in 383 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in 376 a [...] | 0.896 |
fadD36 | fadE32 | Rv1193 | Rv3563 | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Rv3563, (MTCY06G11.10), len: 319 aa. Probable fadE32, acyl-CoA dehydrogenase, similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285, E(): 4.1e-10,(30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 230,E(): 1.1e-07, (25.5% identity in [...] | 0.781 |
fadD36 | fadE33 | Rv1193 | Rv3564 | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Rv3564, (MTCY06G11.11), len: 318 aa. Probable fadE33, acyl-CoA dehydrogenase, similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity in 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95% identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from Streptomyces coelicolor (395 aa), FASTA scores: opt: 273, E(): 2.5e-09,(30.1% identity in 352 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 478,E(): 7.9e-22, (32.9% identity [...] | 0.826 |
fadD36 | fadE34 | Rv1193 | Rv3573c | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Probable acyl-CoA dehydrogenase FadE34; Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the highly specific dehydrogenation of acyl-CoA ester side chains of 3- oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24- oyl-CoA. | 0.832 |
fadD36 | fadE5 | Rv1193 | Rv0244c | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Rv0244c, (MTV034.10c), len: 611 aa. Probable fadE5,acyl-CoA dehydrogenase, equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa), FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa), FASTA scores: opt: 2576, E(): 0,(64.6% identity in 611 aa overlap); and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229, E(): 6.8e-08,(29.8% identity in 409 aa overlap); etc. | 0.729 |
fadD36 | ltp2 | Rv1193 | Rv3540c | Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to th [...] | Rv3540c, (MTCY03C7.16), len: 386 aa. Probable ltp2,lipid-transfer protein or keto acyl-CoA thiolase, similar to several e.g. Q9X4X2|DITF DITF protein (hypothetical protein, similar to non-specific lipid-transfer protein and 3-ketoacyl-CoA thiolase) from Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, E(): 5.3e-34, (33.4% identity in 392 aa overlap); O30255|AF2416 3-ketoacyl-CoA thiolase (ACAB-12) from Archaeoglobus fulgidus (384 aa),FASTA scores: opt: 496, E(): 1.6e-23, (30.35% identity in 389 aa overlap); O28978|AF1291 3-ketoacyl-CoA thiolase (ACAB-11) from Archaeoglobus f [...] | 0.725 |