node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1204c | fadD6 | Rv1204c | Rv1206 | Rv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa), FASTA scores: opt: 215,E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | 0.472 |
Rv1204c | gpgS | Rv1204c | Rv1208 | Rv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa), FASTA scores: opt: 215,E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | 0.430 |
Rv1204c | log | Rv1204c | Rv1205 | Rv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa), FASTA scores: opt: 215,E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. | Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...] | 0.549 |
Rv2491 | log | Rv2491 | Rv1205 | Rv2491, (MTV008.47), len: 207 aa. Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293, E(): 2.8e-11, (42.85% identity in 126 aa overlap); O66531|AQ_134 from Aquifex aeolicus (151 aa), FASTA scores: opt: 261, E(): 2.6e-09,(37.75% identity in 106 aa overlap); Q9HKU3|TA0501 from Thermoplasma acidophilum (161 aa), FASTA scores: opt: 260,E(): 3.2e-09, (35.9% identity in 117 aa overlap); etc. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...] | 0.809 |
Rv3282 | log | Rv3282 | Rv1205 | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. | Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...] | 0.689 |
Rv3282 | miaA | Rv3282 | Rv2727c | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.472 |
fadD6 | Rv1204c | Rv1206 | Rv1204c | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | Rv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa), FASTA scores: opt: 215,E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. | 0.472 |
fadD6 | folP2 | Rv1206 | Rv1207 | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism. | 0.798 |
fadD6 | gpgS | Rv1206 | Rv1208 | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | 0.818 |
fadD6 | log | Rv1206 | Rv1205 | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...] | 0.853 |
fadD6 | tagA | Rv1206 | Rv1210 | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | Rv1210, (MTCI364.22), len: 204 aa. Probable tagA,DNA-3-methyladenine glycosidase I (see citation below),similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap); similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores: opt: 1042, E(): 0, (80.2% identity in 192 aa overlap). | 0.756 |
folP2 | fadD6 | Rv1207 | Rv1206 | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism. | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | 0.798 |
folP2 | gpgS | Rv1207 | Rv1208 | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism. | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | 0.915 |
folP2 | log | Rv1207 | Rv1205 | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism. | Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...] | 0.750 |
folP2 | tagA | Rv1207 | Rv1210 | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism. | Rv1210, (MTCI364.22), len: 204 aa. Probable tagA,DNA-3-methyladenine glycosidase I (see citation below),similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap); similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores: opt: 1042, E(): 0, (80.2% identity in 192 aa overlap). | 0.830 |
gpgS | Rv1204c | Rv1208 | Rv1204c | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | Rv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa), FASTA scores: opt: 215,E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A. | 0.430 |
gpgS | fadD6 | Rv1208 | Rv1206 | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. | 0.818 |
gpgS | folP2 | Rv1208 | Rv1207 | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism. | 0.915 |
gpgS | log | Rv1208 | Rv1205 | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...] | 0.845 |
gpgS | tagA | Rv1208 | Rv1210 | Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3- phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). | Rv1210, (MTCI364.22), len: 204 aa. Probable tagA,DNA-3-methyladenine glycosidase I (see citation below),similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap); similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores: opt: 1042, E(): 0, (80.2% identity in 192 aa overlap). | 0.826 |