node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1215c | Rv1216c | Rv1215c | Rv1216c | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | 0.927 |
Rv1215c | Rv1217c | Rv1215c | Rv1217c | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | 0.936 |
Rv1215c | Rv1218c | Rv1215c | Rv1218c | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | Probable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable). | 0.900 |
Rv1215c | drrC | Rv1215c | Rv2938 | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | 0.610 |
Rv1215c | raaS | Rv1215c | Rv1219c | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | Probable transcriptional regulatory protein; Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene. Important for survival in prolonged stationary phase and during macrophage infection. May be used to eliminate non- growing mycobacteria. | 0.943 |
Rv1216c | Rv1215c | Rv1216c | Rv1215c | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | 0.927 |
Rv1216c | Rv1217c | Rv1216c | Rv1217c | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | 0.964 |
Rv1216c | Rv1218c | Rv1216c | Rv1218c | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | Probable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable). | 0.901 |
Rv1216c | raaS | Rv1216c | Rv1219c | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | Probable transcriptional regulatory protein; Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene. Important for survival in prolonged stationary phase and during macrophage infection. May be used to eliminate non- growing mycobacteria. | 0.916 |
Rv1217c | Rv1215c | Rv1217c | Rv1215c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | 0.936 |
Rv1217c | Rv1216c | Rv1217c | Rv1216c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | 0.964 |
Rv1217c | Rv1218c | Rv1217c | Rv1218c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Probable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable). | 0.999 |
Rv1217c | Rv1272c | Rv1217c | Rv1272c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Probable drugs-transport transmembrane ATP-binding protein ABC transporter; ABC transporter involved in fatty acid import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable). | 0.460 |
Rv1217c | Rv1686c | Rv1217c | Rv1686c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Rv1686c, (MTCI125.08c), len: 226 aa. Probable conserved integral membrane protein ABC transporter (see citation below), similar to AL049819|SCE7.05 putative integral membrane protein from Streptomyces coelicolor (266 aa), FASTA sacores: opt: 661, E(): 0, (45.1% identity in 226 aa overlap); and Q53627|U43537 membrane protein involved in mithramycin resistance from streptomyces argillaceus (233 aa), FASTA scores: opt: 222, E(): 5.4e-10,(28.7% identity in 216 aa overlap). | 0.878 |
Rv1217c | drrB | Rv1217c | Rv2937 | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB; Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | 0.558 |
Rv1217c | drrC | Rv1217c | Rv2938 | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | 0.600 |
Rv1217c | raaS | Rv1217c | Rv1219c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Probable transcriptional regulatory protein; Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene. Important for survival in prolonged stationary phase and during macrophage infection. May be used to eliminate non- growing mycobacteria. | 0.983 |
Rv1217c | tap | Rv1217c | Rv1258c | Probable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Probably responsible for the translocation of the substrate across the membrane (Probable). | Probable conserved integral membrane transport protein; Efflux pump that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy (By similarity). Confers resistance to rifampicin. Confers low-level resistance to tetracycline and to several aminoglycosides, including streptomycin, gentamicin, 2'-N- ethylnetilmicin and 6'-N-ethylnetilmicin. | 0.656 |
Rv1218c | Rv1215c | Rv1218c | Rv1215c | Probable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable). | Conserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap). | 0.900 |
Rv1218c | Rv1216c | Rv1218c | Rv1216c | Probable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable). | Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap). | 0.901 |