STRINGSTRING
rho protein (Mycobacterium tuberculosis H37Rv) - STRING interaction network
"rho" - Transcription termination factor Rho in Mycobacterium tuberculosis H37Rv
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho’s RNA-dependent ATPase activity, and release of the mRNA from the DNA template. Shows poor RNA-dependent ATP hydrolysis and inefficient DNA-RNA unwinding activities, but exhibits robust and fast transcription termination, which suggests that the transcription termination function of M.tuberculosis Rho is not correlated with its helicase/translocase activities and that these functions may not be important for its RNA release process (602 aa)    
Predicted Functional Partners:
nusG
Transcription termination/antitermination protein NusG; Participates in transcription elongation, termination and antitermination (238 aa)
   
 
  0.973
greA
Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3’terminus. GreA releases sequences of 2 to 3 nucleotides (164 aa)
   
 
 
  0.871
rpsJ
30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes (101 aa)
   
   
  0.867
nusB
Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons (156 aa)
 
   
  0.866
mfd
Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily (1234 aa)
 
     
  0.852
nusA
Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination; Belongs to the NusA family (347 aa)
 
 
  0.780
rpmE
50S ribosomal protein L31; Binds the 23S rRNA (80 aa)
   
   
  0.773
rpoC
DNA-directed RNA polymerase subunit beta’; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1316 aa)
 
   
  0.746
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3’-5’ and 5’-3’ exonuclease activity; Belongs to the DNA polymerase type-A family (904 aa)
   
   
  0.744
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (357 aa)
 
   
  0.740
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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