node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1421 | Rv1422 | Rv1421 | Rv1422 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | 0.972 |
Rv1421 | ribA2 | Rv1421 | Rv1415 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.702 |
Rv1421 | uvrC | Rv1421 | Rv1420 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.893 |
Rv1421 | whiA | Rv1421 | Rv1423 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.948 |
Rv1422 | Rv1421 | Rv1422 | Rv1421 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 0.972 |
Rv1422 | ribA2 | Rv1422 | Rv1415 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.687 |
Rv1422 | uvrC | Rv1422 | Rv1420 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.890 |
Rv1422 | whiA | Rv1422 | Rv1423 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.969 |
recR | ruvA | Rv3715c | Rv2593c | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Probable holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.698 |
recR | ruvB | Rv3715c | Rv2592c | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Probable holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.821 |
recR | uvrA | Rv3715c | Rv1638 | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. Belongs to the ABC transporter superfamily. UvrA family. | 0.714 |
recR | uvrB | Rv3715c | Rv1633 | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Probable excinuclease ABC (subunit B-helicase) UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the [...] | 0.711 |
recR | uvrC | Rv3715c | Rv1420 | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.770 |
recR | uvrD1 | Rv3715c | Rv0949 | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Probable ATP-dependent DNA helicase II UvrD1; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. A minimal tail of 18 nt is required for activity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair, as well as in nitrosative and oxidative stress response and possibly in persistence in the host. Inhibits RecA-mediated DNA strand exchange; this does not require ATPase activity. When combined with UvrA greatly inhibits RecA- mediated DNA strand exchange; Belongs to the helicase family. UvrD sub [...] | 0.761 |
ribA2 | Rv1421 | Rv1415 | Rv1421 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 0.702 |
ribA2 | Rv1422 | Rv1415 | Rv1422 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | 0.687 |
ribA2 | uvrA | Rv1415 | Rv1638 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. Belongs to the ABC transporter superfamily. UvrA family. | 0.507 |
ribA2 | uvrC | Rv1415 | Rv1420 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.802 |
ribA2 | whiA | Rv1415 | Rv1423 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.685 |
ruvA | recR | Rv2593c | Rv3715c | Probable holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Probable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.698 |