node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1158c | Rv1421 | Rv1158c | Rv1421 | Rv1158c, (MTCI65.25c), len: 227 aa. Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: opt: 367, E(): 1.2e-08,(36.3% identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 0.695 |
Rv1417 | Rv1421 | Rv1417 | Rv1421 | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 0.696 |
Rv1417 | Rv1422 | Rv1417 | Rv1422 | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | 0.691 |
Rv1417 | ribA2 | Rv1417 | Rv1415 | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.902 |
Rv1417 | ribH | Rv1417 | Rv1416 | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.976 |
Rv1417 | uvrC | Rv1417 | Rv1420 | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.685 |
Rv1417 | whiA | Rv1417 | Rv1423 | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.696 |
Rv1421 | Rv1158c | Rv1421 | Rv1158c | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Rv1158c, (MTCI65.25c), len: 227 aa. Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: opt: 367, E(): 1.2e-08,(36.3% identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.695 |
Rv1421 | Rv1417 | Rv1421 | Rv1417 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | 0.696 |
Rv1421 | Rv1422 | Rv1421 | Rv1422 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | 0.972 |
Rv1421 | fbiA | Rv1421 | Rv3261 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Probable F420 biosynthesis protein FbiA; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP; Belongs to the CofD family. | 0.732 |
Rv1421 | mrsA | Rv1421 | Rv3441c | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Probable phospho-sugar mutase / MrsA protein homolog; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. | 0.663 |
Rv1421 | ribA2 | Rv1421 | Rv1415 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.702 |
Rv1421 | ribH | Rv1421 | Rv1416 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.689 |
Rv1421 | rne | Rv1421 | Rv2444c | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Rv2444c, (MTCY428.02), len: 953 aa. Possible rne,ribonuclease E, highly similar to others e.g. Q9CBZ1|ML1468 possible ribonuclease from Mycobacterium leprae (924 aa),FASTA scores: opt: 3713, E(): 2.4e-174, (74.2% identity in 966 aa overlap); Q9SI08|AT2G04270 putative ribonuclease E from Arabidopsis thaliana (502 aa), FASTA scores: opt: 674,E(): 7.5e-26, (31.2% identity in 410 aa overlap); etc. Similar at C-terminal end to P21513|RNE_ECOLI|ams|HMP1|B1084 ribonuclease E (RNASE E) from Escherichia coli strain K12 (1061 aa), FASTA scores: opt: 554, E(): 9.9e-20, (37.8% identity in 386 aa o [...] | 0.700 |
Rv1421 | uvrC | Rv1421 | Rv1420 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.893 |
Rv1421 | whiA | Rv1421 | Rv1423 | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.948 |
Rv1422 | Rv1417 | Rv1422 | Rv1417 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap). | 0.691 |
Rv1422 | Rv1421 | Rv1422 | Rv1421 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family. | 0.972 |
Rv1422 | ribA2 | Rv1422 | Rv1415 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.687 |