node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1566c | pirG | Rv1566c | Rv3810 | Possible Inv protein; Rv1566c, (MTCY336.37), len: 230 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390, O07391) from Mycobacterium avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478,Rv0024, Rv2190c. Predicted to be an outer membrane protein (See Song et al. [...] | Exported repetitive protein precursor PirG (cell surface protein) (EXP53); Surface-exposed protein required for multiplication and intracellular growth; To M.leprae 28 kDa antigen. | 0.809 |
Rv1566c | ripA | Rv1566c | Rv1477 | Possible Inv protein; Rv1566c, (MTCY336.37), len: 230 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390, O07391) from Mycobacterium avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478,Rv0024, Rv2190c. Predicted to be an outer membrane protein (See Song et al. [...] | Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Belongs to the peptidase C40 family. | 0.848 |
Rv1566c | ripB | Rv1566c | Rv1478 | Possible Inv protein; Rv1566c, (MTCY336.37), len: 230 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390, O07391) from Mycobacterium avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478,Rv0024, Rv2190c. Predicted to be an outer membrane protein (See Song et al. [...] | Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. | 0.843 |
Rv1566c | rpfB | Rv1566c | Rv1009 | Possible Inv protein; Rv1566c, (MTCY336.37), len: 230 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390, O07391) from Mycobacterium avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478,Rv0024, Rv2190c. Predicted to be an outer membrane protein (See Song et al. [...] | Probable resuscitation-promoting factor RpfB; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity; Belongs to the transglycosylase family. Rpf subfamily. | 0.611 |
Rv3717 | chiZ | Rv3717 | Rv2719c | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | 0.415 |
Rv3717 | cwlM | Rv3717 | Rv3915 | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D- isoglutamine, releasing free N-acetylmuramic acid and dipeptide. | 0.989 |
Rv3717 | ftsW | Rv3717 | Rv2154c | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | FtsW-like protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.771 |
Rv3717 | ripA | Rv3717 | Rv1477 | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Belongs to the peptidase C40 family. | 0.916 |
Rv3717 | ripB | Rv3717 | Rv1478 | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. | 0.676 |
chiZ | Rv3717 | Rv2719c | Rv3717 | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | 0.415 |
chiZ | cwlM | Rv2719c | Rv3915 | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D- isoglutamine, releasing free N-acetylmuramic acid and dipeptide. | 0.498 |
chiZ | ftsW | Rv2719c | Rv2154c | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | FtsW-like protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.421 |
chiZ | pirG | Rv2719c | Rv3810 | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | Exported repetitive protein precursor PirG (cell surface protein) (EXP53); Surface-exposed protein required for multiplication and intracellular growth; To M.leprae 28 kDa antigen. | 0.764 |
chiZ | ripA | Rv2719c | Rv1477 | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Belongs to the peptidase C40 family. | 0.843 |
chiZ | ripB | Rv2719c | Rv1478 | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. | 0.684 |
chiZ | rpfB | Rv2719c | Rv1009 | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | Probable resuscitation-promoting factor RpfB; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity; Belongs to the transglycosylase family. Rpf subfamily. | 0.439 |
cwlM | Rv3717 | Rv3915 | Rv3717 | Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D- isoglutamine, releasing free N-acetylmuramic acid and dipeptide. | Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity. May have a role in peptidoglycan fragment recycling. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | 0.989 |
cwlM | chiZ | Rv3915 | Rv2719c | Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D- isoglutamine, releasing free N-acetylmuramic acid and dipeptide. | Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ. | 0.498 |
cwlM | ripA | Rv3915 | Rv1477 | Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D- isoglutamine, releasing free N-acetylmuramic acid and dipeptide. | Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Belongs to the peptidase C40 family. | 0.875 |
cwlM | ripB | Rv3915 | Rv1478 | Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D- isoglutamine, releasing free N-acetylmuramic acid and dipeptide. | Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. | 0.676 |