node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0958 | Rv1481 | Rv0958 | Rv1481 | Rv0958, (MTCY10D7.16c), len: 459 aa. Possible magnesium chelatase, similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA magnesium-chelatase subunit CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | 0.713 |
Rv0958 | Rv2850c | Rv0958 | Rv2850c | Rv0958, (MTCY10D7.16c), len: 459 aa. Possible magnesium chelatase, similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA magnesium-chelatase subunit CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Rv2850c, (MTCY24A1.07), len: 629 aa. Possible magnesium-chelatase, highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c putative chelatase from Streptomyces coelicolor (672 aa),FASTA scores: opt: 1941, E(): 2.1e-85, (54.65% identity in 675 aa overlap); Q9HZQ5|PA2942 probable magnesium chelatase from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 991, E(): 2.7e-40, (49.45% identity in 368 aa overlap); O33549|BCHI mg protoporphyrin IX chelatase subunit from Rhodobacter sphaeroides (Rhod [...] | 0.966 |
Rv0958 | hemZ | Rv0958 | Rv1485 | Rv0958, (MTCY10D7.16c), len: 459 aa. Possible magnesium chelatase, similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA magnesium-chelatase subunit CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme. | 0.926 |
Rv1480 | Rv1481 | Rv1480 | Rv1481 | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | 0.994 |
Rv1480 | hemZ | Rv1480 | Rv1485 | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme. | 0.550 |
Rv1480 | moxR1 | Rv1480 | Rv1479 | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | Rv1479, (MTV007.26), len: 377 aa. Probable moxR1,transcriptional regulatory protein, similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa), FASTA scores: opt: 850, E():0, (43.5% identity in 317 aa overlap); and P. denitrificans. Highly similar to MoxR homologs of Mycobacterium tuberculosis and Mycobacterium avium (but these both differ at C-terminus) e.g. Rv3692, Rv3164c, and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in 227 aa overlap). Also similar to O33173|AF006054 MoxR fragment from Mycoba [...] | 0.986 |
Rv1480 | ripA | Rv1480 | Rv1477 | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Belongs to the peptidase C40 family. | 0.587 |
Rv1480 | ripB | Rv1480 | Rv1478 | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. | 0.573 |
Rv1480 | rnhB | Rv1480 | Rv2902c | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | Probable ribonuclease HII protein RnhB (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.586 |
Rv1481 | Rv0958 | Rv1481 | Rv0958 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Rv0958, (MTCY10D7.16c), len: 459 aa. Possible magnesium chelatase, similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA magnesium-chelatase subunit CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | 0.713 |
Rv1481 | Rv1480 | Rv1481 | Rv1480 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693; To M.avium MAV169. | 0.994 |
Rv1481 | Rv2190c | Rv1481 | Rv2190c | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Conserved hypothetical protein; Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477,Rv1478, Rv1566c, Rv0024, that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE protein P60 precursor (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap; Belongs to the peptidase C [...] | 0.682 |
Rv1481 | Rv2850c | Rv1481 | Rv2850c | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Rv2850c, (MTCY24A1.07), len: 629 aa. Possible magnesium-chelatase, highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c putative chelatase from Streptomyces coelicolor (672 aa),FASTA scores: opt: 1941, E(): 2.1e-85, (54.65% identity in 675 aa overlap); Q9HZQ5|PA2942 probable magnesium chelatase from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 991, E(): 2.7e-40, (49.45% identity in 368 aa overlap); O33549|BCHI mg protoporphyrin IX chelatase subunit from Rhodobacter sphaeroides (Rhod [...] | 0.690 |
Rv1481 | hemZ | Rv1481 | Rv1485 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme. | 0.591 |
Rv1481 | mce2B | Rv1481 | Rv0590 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Mce-family protein Mce2B; Rv0590, (MTCY19H5.32c), len: 275 aa. Mce2B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); P45391|YRBD_ECOLI hypothetical 19.6 kDa protein from Escherichia coli (183 aa), FASTA scores: opt: 160, E(): 0.00099, (28.3% identity in 166 aa overlap); P45029|YRBD_HAEIN| [...] | 0.703 |
Rv1481 | moxR1 | Rv1481 | Rv1479 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Rv1479, (MTV007.26), len: 377 aa. Probable moxR1,transcriptional regulatory protein, similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa), FASTA scores: opt: 850, E():0, (43.5% identity in 317 aa overlap); and P. denitrificans. Highly similar to MoxR homologs of Mycobacterium tuberculosis and Mycobacterium avium (but these both differ at C-terminus) e.g. Rv3692, Rv3164c, and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in 227 aa overlap). Also similar to O33173|AF006054 MoxR fragment from Mycoba [...] | 0.990 |
Rv1481 | ripA | Rv1481 | Rv1477 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Belongs to the peptidase C40 family. | 0.805 |
Rv1481 | ripB | Rv1481 | Rv1478 | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. | 0.916 |
Rv1481 | rnhB | Rv1481 | Rv2902c | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | Probable ribonuclease HII protein RnhB (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.604 |
Rv2190c | Rv1481 | Rv2190c | Rv1481 | Conserved hypothetical protein; Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477,Rv1478, Rv1566c, Rv0024, that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE protein P60 precursor (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap; Belongs to the peptidase C [...] | Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap). | 0.682 |