STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv1519Rv1519, (MTCY19G5.09c), len: 89 aa. Conserved hypothetical protein, high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa overlap); To M.tuberculosis Rv3402c. (89 aa)    
Predicted Functional Partners:
Rv2313c
Hypothetical protein; Rv2313c, (MTCY3G12.21), len: 284 aa. Hypothetical unknown protein; To E.coli YnjA.
      
 0.870
Rv3517
Rv3517, (MTV023.24), len: 279 aa. Hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis strain H37Rv (339 aa) (alias AAK45794|MT1529 from Mycobacterium tuberculosis strain CDC1551 (292 aa) but longer) FASTA scores: opt: 1040, E(): 3.7e-60, (59.0% identity in 273 aa overlap); O07396|MAV346 from Mycobacterium avium (346 aa) FASTA scores: opt: 1018, E(): 1e-58, (57.2% identity in 278 aa overlap); O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis strain H37Rv (283 aa), FASTA scores: opt: 903, E(): [...]
      
 0.808
Rv1735c
Hypothetical membrane protein; Rv1735c, (MTCY04C12.20c), len: 165 aa. Hypothetical membrane protein, similar to part of O58614|PH0884|AP000004 Hypothetical malic acid transport protein from Pyrococcus horikoshii (330 aa), FASTA scores: opt: 167, E(): 0.0003,(29.2% identity in 120 aa overlap).
   
  
 0.804
Rv3126c
Hypothetical protein; Rv3126c, (MTCY164.36c), unknown, len: 104 aa. Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
      
 0.803
Rv3651
Rv3651, (MTCY15C10.01c), len: 345 aa. Hypothetical protein, with some similarity to Q9ZHK1 hypothetical 36.5 KDA protein from Rhodococcus sp. X309 (329 aa) FASTA scores: opt: 332, E(): 3.4e-13, (27.4% identity in 321 aa overlap).
      
 0.803
Rv1520
Rv1520, (MTCY19G5.08c), len: 346 aa. Probable sugar transferase, similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa), FASTA scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa overlap); O34234|Y07786 sugar transferase from Vibrio cholerae (337 aa), FASTA scores: opt: 214, E(): 8.4e-05,(25.9% identity in 212 aa overlap). Also strongly similar to Mycobacterium tuberculosis probable sugar transferase Rv1516c. Alternative nucleotide at position 1711627 (C->T; Y200Y) has been observed.
  
  
 0.787
hycQ
Rv0086, (MTCY251.04), len: 488 aa. Possible hycQ,hydrogenase, integral membrane protein. Belongs to the NADH-Ubiquinone/plastoquinone (complex I) superfamily.
   
  
 0.654
PPE66
Rv3738c, (MTV025.086c), len: 315 aa. PPE66, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa),FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c|Rv3739c|PPE67. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF,observed in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation, but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35 [...]
   
  
 0.651
hycP
Rv0085, (MTCY251.03), len: 220 aa. Possible hycP,hydrogenase, integral membrane protein. Belongs to NADH-ubiquinone/plastoquinone oxidoreductase chain 4L superfamily.
   
  
 0.625
Rv1518
Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap).
  
  
 0.604
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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