node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1138c | Rv1139c | Rv1138c | Rv1139c | Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89,E(): 4.5e-09, (24.6% identity in 358 aa overlap). | Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740,Rv0750. | 0.988 |
Rv1138c | pks10 | Rv1138c | Rv1660 | Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89,E(): 4.5e-09, (24.6% identity in 358 aa overlap). | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | 0.905 |
Rv1138c | pks11 | Rv1138c | Rv1665 | Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89,E(): 4.5e-09, (24.6% identity in 358 aa overlap). | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | 0.847 |
Rv1139c | Rv1138c | Rv1139c | Rv1138c | Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740,Rv0750. | Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89,E(): 4.5e-09, (24.6% identity in 358 aa overlap). | 0.988 |
Rv1139c | pks10 | Rv1139c | Rv1660 | Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740,Rv0750. | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | 0.926 |
Rv1139c | pks11 | Rv1139c | Rv1665 | Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740,Rv0750. | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | 0.904 |
pks10 | Rv1138c | Rv1660 | Rv1138c | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89,E(): 4.5e-09, (24.6% identity in 358 aa overlap). | 0.905 |
pks10 | Rv1139c | Rv1660 | Rv1139c | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740,Rv0750. | 0.926 |
pks10 | pks11 | Rv1660 | Rv1665 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | 0.812 |
pks10 | pks17 | Rv1660 | Rv1663 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Rv1663, (MTCY275.02), len: 502 aa. Probable pks17,polyketide synthase, similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0,(43.9% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks1. Note that the similarity extends into the upstream ORF Rv1662 (MTCY275.01) and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy w [...] | 0.909 |
pks10 | pks4 | Rv1660 | Rv1181 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Probable polyketide beta-ketoacyl synthase Pks4; Polyketide synthase involved in the biosynthesis of methyl- branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of three methylmalonyl (but not malonyl) residues, to form trimethyl-branched fatty-acids. | 0.830 |
pks10 | pks9 | Rv1660 | Rv1664 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Rv1664, (MTCY275.03), len: 1017 aa. Probable pks9,polyketide synthase, similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase, modules 5 and 6 from Streptomyces antibioticus (3519 aa), FASTA scores: opt: 1767, E(): 0, (41.6% identity in 919 aa overlap). Similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks6, pks8, etc. Contains PS00012 Phosphopantetheine attachment site. | 0.780 |
pks10 | ppsA | Rv1660 | Rv2931 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Phenolpthiocerol synthesis type-I polyketide synthase PpsA; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. | 0.817 |
pks10 | ppsB | Rv1660 | Rv2932 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Phenolpthiocerol synthesis type-I polyketide synthase PpsB; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. | 0.873 |
pks10 | ppsC | Rv1660 | Rv2933 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Phenolpthiocerol synthesis type-I polyketide synthase PpsC; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. | 0.887 |
pks10 | ppsD | Rv1660 | Rv2934 | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | Phenolpthiocerol synthesis type-I polyketide synthase PpsD; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. | 0.776 |
pks11 | Rv1138c | Rv1665 | Rv1138c | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89,E(): 4.5e-09, (24.6% identity in 358 aa overlap). | 0.847 |
pks11 | Rv1139c | Rv1665 | Rv1139c | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740,Rv0750. | 0.904 |
pks11 | pks10 | Rv1665 | Rv1660 | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | 0.812 |
pks11 | pks17 | Rv1665 | Rv1663 | Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | Rv1663, (MTCY275.02), len: 502 aa. Probable pks17,polyketide synthase, similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0,(43.9% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks1. Note that the similarity extends into the upstream ORF Rv1662 (MTCY275.01) and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy w [...] | 0.959 |