STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Rv1828Conserved protein; Transcriptional regulator that binds to its own promoter and thus may play a role in the regulation of the cotranscribed genes Rv1827 and Rv1828. Can also bind several promoter regions of genes that are essential, including ftsZ. Binds to the imperfect everted repeat sequence CTCAA through its winged-HTH motif. (247 aa)    
Predicted Functional Partners:
garA
Conserved protein with FHA domain, GarA; Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB.
 
  
 0.918
Rv1829
Conserved protein; Rv1829, (MTCY1A11.14c), len: 164 aa. Conserved protein, equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa),FASTA scores: opt: 1011, E(): 0, (95.1% identity in 164 aa overlap). Also present in Aquifex aeolicus, etc.
  
  
 0.829
whiA
Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation.
   
  
 0.826
Rv0472c
Rv0472c, (MTV038.16c), len: 234 aa. Probable regulatory protein, possibly TetR family, equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae (233 aa). Also similar to CAC01492.1|AL391017 putative transcriptional regulatory protein from Streptomyces coelicolor (218 aa); and CAC01371.1|AL390975 putative TetR-family transcriptional regulator from Streptomyces coelicolor (228 aa). Also similar to AL0212|MTV012_65 from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% identity in 232 aa overlap); and Z95120 [...]
   
  
 0.813
Rv1816
Rv1816, (MTCY1A11.27c), len: 234 aa. Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators, Rv0653c, Rv0681. Contains helix-turn-helix motif at aa 38-59 (+4.30 SD).
   
  
 0.813
Rv1332
Rv1332, (MTCY130.17), len: 218 aa. Possible regulatory protein, high similarity to ML014|U00014 M. leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): 0, (75.6% identity in 221 aa overlap). Helix turn helix motif fram aa 8-29 (+3.03 SD); To M.leprae ML1166.
   
  
 0.779
Rv1830
Rv1830, (MTCY1A11.13c), len: 225 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa),FASTA scores: opt: 1307, E(): 0, (89.6% identity in 231 aa overlap).
 
  
 0.716
gcvH
Probable glycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
    0.709
Rv1824
Rv1824, (MTCY1A11.19c), len: 121 aa. Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa), FASTA scores: opt: 261, E(): 1.9e-12, (38.9% identity in 113 aa overlap).
  
    0.696
Rv1823
Conserved protein; Rv1823, (MTCY01A11.20), len: 307 aa. Conserved protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical protein CY10H4.12 from Mycobacterium tuberculosis (262 aa),FASTA scores: opt: 304, E(): 1.5e-12, (30.1% identity in 246 aa overlap).
  
    0.684
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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