node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE_PGRS23 | PE_PGRS37 | Rv1243c | Rv2126c | PE-PGRS family protein PE_PGRS23; Rv1243c, (MTV006.15c), len: 562 aa. PE_PGRS23,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | 0.773 |
PE_PGRS23 | lipZ | Rv1243c | Rv1834 | PE-PGRS family protein PE_PGRS23; Rv1243c, (MTV006.15c), len: 562 aa. PE_PGRS23,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.659 |
PE_PGRS37 | PE_PGRS23 | Rv2126c | Rv1243c | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | PE-PGRS family protein PE_PGRS23; Rv1243c, (MTV006.15c), len: 562 aa. PE_PGRS23,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). | 0.773 |
PE_PGRS37 | lipZ | Rv2126c | Rv1834 | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.700 |
dhmA2 | lipZ | Rv1833c | Rv1834 | Possible haloalkane dehalogenase; Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.667 |
lipC | lipF | Rv0220 | Rv3487c | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | 0.796 |
lipC | lipV | Rv0220 | Rv3203 | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP- decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress. | 0.459 |
lipC | lipY | Rv0220 | Rv3097c | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Triacylglycerol lipase; Responsible for the utilization of stored long-chain triacylglycerol (TG) during dormancy and reactivation stage of the infection cycle. Catalyzes the hydrolysis of long-chain triacylglycerol with high specific activity; In the C-terminal section; belongs to the 'GDXG' lipolytic enzyme family. | 0.803 |
lipC | lipZ | Rv0220 | Rv1834 | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.870 |
lipC | nlhH | Rv0220 | Rv1399c | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Probable non lipolytic carboxylesterase NlhH; Hydrolyzes various short-chain esters, such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates. | 0.514 |
lipD | lipP | Rv1923 | Rv2463 | Probable lipase LipD; Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD,hydrolase lipase, similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569,E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. | Rv2463, (MTV008.19), len: 394 aa. Probable lipP,esterase, lipase similar to others eg O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa overlap); Q9I4S7|PA1047 probable esterase from Pseudomonas aeruginosa (392 aa), FASTA scores: opt: 863, E(): 4.6e-47,(40.05% identity in 377 aa overlap); Q53403|ESTC esterase III from Pseudomonas fluorescens (382 aa), FASTA scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa overlap); etc. | 0.459 |
lipD | lipV | Rv1923 | Rv3203 | Probable lipase LipD; Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD,hydrolase lipase, similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569,E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. | Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP- decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress. | 0.643 |
lipD | lipZ | Rv1923 | Rv1834 | Probable lipase LipD; Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD,hydrolase lipase, similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569,E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.655 |
lipF | lipC | Rv3487c | Rv0220 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | 0.796 |
lipF | lipV | Rv3487c | Rv3203 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP- decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress. | 0.617 |
lipF | lipY | Rv3487c | Rv3097c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Triacylglycerol lipase; Responsible for the utilization of stored long-chain triacylglycerol (TG) during dormancy and reactivation stage of the infection cycle. Catalyzes the hydrolysis of long-chain triacylglycerol with high specific activity; In the C-terminal section; belongs to the 'GDXG' lipolytic enzyme family. | 0.856 |
lipF | lipZ | Rv3487c | Rv1834 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.803 |
lipF | nlhH | Rv3487c | Rv1399c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable non lipolytic carboxylesterase NlhH; Hydrolyzes various short-chain esters, such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates. | 0.483 |
lipP | lipD | Rv2463 | Rv1923 | Rv2463, (MTV008.19), len: 394 aa. Probable lipP,esterase, lipase similar to others eg O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa overlap); Q9I4S7|PA1047 probable esterase from Pseudomonas aeruginosa (392 aa), FASTA scores: opt: 863, E(): 4.6e-47,(40.05% identity in 377 aa overlap); Q53403|ESTC esterase III from Pseudomonas fluorescens (382 aa), FASTA scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa overlap); etc. | Probable lipase LipD; Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD,hydrolase lipase, similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569,E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. | 0.459 |
lipP | lipV | Rv2463 | Rv3203 | Rv2463, (MTV008.19), len: 394 aa. Probable lipP,esterase, lipase similar to others eg O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa overlap); Q9I4S7|PA1047 probable esterase from Pseudomonas aeruginosa (392 aa), FASTA scores: opt: 863, E(): 4.6e-47,(40.05% identity in 377 aa overlap); Q53403|ESTC esterase III from Pseudomonas fluorescens (382 aa), FASTA scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa overlap); etc. | Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP- decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress. | 0.656 |