node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1410c | lppG | Rv1410c | Rv1946c | Aminoglycosides/tetracycline-transport integral membrane protein; In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation. Confers resistance to ethidium bromide, possibly acting as an efflux pump, requires LprG lipoprotein for normal function. With LprG maintains cell wall permeability. Probably required with LprG for normal surface localization of LAM. Overexpression of LprG and Rv1410c leads to increased levels of TAG in the culture medium. Belong [...] | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.431 |
Rv1947 | lppG | Rv1947 | Rv1946c | Hypothetical protein; Rv1947, (MTCY09F9.17c), len: 133 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.570 |
Rv2963 | lppG | Rv2963 | Rv1946c | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.653 |
Rv2963 | lpqS | Rv2963 | Rv0847 | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | 0.974 |
Rv2963 | mymT | Rv2963 | Rv0186A | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | 0.870 |
Rv2963 | ricR | Rv2963 | Rv0190 | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection. | 0.885 |
lppG | Rv1410c | Rv1946c | Rv1410c | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Aminoglycosides/tetracycline-transport integral membrane protein; In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation. Confers resistance to ethidium bromide, possibly acting as an efflux pump, requires LprG lipoprotein for normal function. With LprG maintains cell wall permeability. Probably required with LprG for normal surface localization of LAM. Overexpression of LprG and Rv1410c leads to increased levels of TAG in the culture medium. Belong [...] | 0.431 |
lppG | Rv1947 | Rv1946c | Rv1947 | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Hypothetical protein; Rv1947, (MTCY09F9.17c), len: 133 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.570 |
lppG | Rv2963 | Rv1946c | Rv2963 | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | 0.653 |
lppG | lpqS | Rv1946c | Rv0847 | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | 0.531 |
lppG | mymT | Rv1946c | Rv0186A | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | 0.510 |
lppG | ricR | Rv1946c | Rv0190 | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection. | 0.542 |
lpqS | Rv2963 | Rv0847 | Rv2963 | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | 0.974 |
lpqS | lppG | Rv0847 | Rv1946c | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.531 |
lpqS | mymT | Rv0847 | Rv0186A | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | 0.870 |
lpqS | ricR | Rv0847 | Rv0190 | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection. | 0.883 |
mymT | Rv2963 | Rv0186A | Rv2963 | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein. | 0.870 |
mymT | lppG | Rv0186A | Rv1946c | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | Possible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.510 |
mymT | lpqS | Rv0186A | Rv0847 | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell. | 0.870 |
mymT | ricR | Rv0186A | Rv0190 | Metallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. | Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection. | 0.870 |