STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vapC35Possible toxin VapC35. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB35.; Belongs to the PINc/VapC protein family. (135 aa)    
Predicted Functional Partners:
vapB35
Possible antitoxin VapB35; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC35.
       0.882
vapB46
Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46.
 
    0.766
mce3R
Probable transcriptional repressor (probably TetR-family) Mce3R; Mce3R represses the transcription of mce3 operon and downregulates its own expression, but does not affect the transcription of mce1, mce2 and mce4 operons.
  
    0.722
vapB47
Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47.
 
     0.712
vapC12
Possible toxin VapC12; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB12 (By similarity). Belongs to the PINc/VapC protein family.
  
    0.592
vapB5
Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5.
 
    0.547
vapC9
Possible toxin VapC9; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB9 (By similarity). Belongs to the PINc/VapC protein family.
  
    0.523
vapC1
Possible toxin VapC1; Toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB1 (By similarity). Has ribonuclease activity.
  
    0.505
vapC3
Possible toxin VapC3; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB3.
  
    0.496
vapC8
Possible toxin VapC8; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB8 (By similarity); Belongs to the PINc/VapC protein family.
 
    0.457
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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