node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0470A | Rv1995 | Rv0470A | Rv1995 | Rv0470A, len: 146 aa. Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and Mycobacterium tuberculosis strain CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132,E(): 1.1, (39.35% identity in 61 aa overlap). | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | 0.543 |
Rv1673c | Rv1995 | Rv1673c | Rv1995 | Rv1673c, (MTV047.08c), len: 310 aa. Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap). | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | 0.613 |
Rv1673c | Rv2434c | Rv1673c | Rv2434c | Rv1673c, (MTV047.08c), len: 310 aa. Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap). | Rv2434c, (MTCY428.12), len: 481 aa. Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 probable integral membrane protein from Rhizobium loti (410 aa), FASTA scores: opt: 298, E(): 4.1e-11, (27.25% identity in 389 aa overlap); and also similarity with other hypothetical proteins and/or putative integral membrane proteins. | 0.804 |
Rv1977 | Rv1993c | Rv1977 | Rv1993c | Conserved protein; Rv1977, (MTV051.15), len: 348 aa. Conserved protein,similar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa), blastp scores: Score = 311 bits (789), Expect = 5e-84 Identities = 156/316 (49%),Positives = 212/316 (66%); and PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA scores: opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Alternative nucleotide at position 2219929 (T->C; L59P) has been observed. | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | 0.546 |
Rv1977 | Rv1995 | Rv1977 | Rv1995 | Conserved protein; Rv1977, (MTV051.15), len: 348 aa. Conserved protein,similar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa), blastp scores: Score = 311 bits (789), Expect = 5e-84 Identities = 156/316 (49%),Positives = 212/316 (66%); and PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA scores: opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Alternative nucleotide at position 2219929 (T->C; L59P) has been observed. | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | 0.511 |
Rv1993c | Rv1977 | Rv1993c | Rv1977 | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Conserved protein; Rv1977, (MTV051.15), len: 348 aa. Conserved protein,similar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa), blastp scores: Score = 311 bits (789), Expect = 5e-84 Identities = 156/316 (49%),Positives = 212/316 (66%); and PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA scores: opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Alternative nucleotide at position 2219929 (T->C; L59P) has been observed. | 0.546 |
Rv1993c | Rv1995 | Rv1993c | Rv1995 | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | 0.918 |
Rv1993c | Rv2075c | Rv1993c | Rv2075c | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Rv2075c, (MTCY49.14c), len: 487 aa. Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. Predicted to be an outer membrane protein (See Song et al.,2008). | 0.650 |
Rv1993c | cmtR | Rv1993c | Rv1994c | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | 0.935 |
Rv1993c | ctpG | Rv1993c | Rv1992c | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.992 |
Rv1993c | fadD25 | Rv1993c | Rv1521 | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. | 0.517 |
Rv1995 | Rv0470A | Rv1995 | Rv0470A | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv0470A, len: 146 aa. Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and Mycobacterium tuberculosis strain CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132,E(): 1.1, (39.35% identity in 61 aa overlap). | 0.543 |
Rv1995 | Rv1673c | Rv1995 | Rv1673c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv1673c, (MTV047.08c), len: 310 aa. Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap). | 0.613 |
Rv1995 | Rv1977 | Rv1995 | Rv1977 | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Conserved protein; Rv1977, (MTV051.15), len: 348 aa. Conserved protein,similar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa), blastp scores: Score = 311 bits (789), Expect = 5e-84 Identities = 156/316 (49%),Positives = 212/316 (66%); and PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA scores: opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Alternative nucleotide at position 2219929 (T->C; L59P) has been observed. | 0.511 |
Rv1995 | Rv1993c | Rv1995 | Rv1993c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | 0.918 |
Rv1995 | Rv1996 | Rv1995 | Rv1996 | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv1996, (MTCY39.23c), len: 317 aa. Universal stress protein family protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt: 775,E(): 0, (50.3% identity in 316 aa overlap); Rv2026c (294 aa) (47.9% identity in 311 aa overlap); and Rv2623, etc. Also similar to SCJ1.30c|AL109962 hypothetical protein from Streptomyces coelicolor (328 aa). Predicted possible vaccine candidate (See Zvi et al., 2008). | 0.706 |
Rv1995 | Rv2075c | Rv1995 | Rv2075c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv2075c, (MTCY49.14c), len: 487 aa. Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. Predicted to be an outer membrane protein (See Song et al.,2008). | 0.602 |
Rv1995 | Rv2434c | Rv1995 | Rv2434c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv2434c, (MTCY428.12), len: 481 aa. Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 probable integral membrane protein from Rhizobium loti (410 aa), FASTA scores: opt: 298, E(): 4.1e-11, (27.25% identity in 389 aa overlap); and also similarity with other hypothetical proteins and/or putative integral membrane proteins. | 0.563 |
Rv1995 | cmtR | Rv1995 | Rv1994c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | 0.732 |
Rv1995 | ctpG | Rv1995 | Rv1992c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.636 |