node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0998 | Rv2026c | Rv0998 | Rv2026c | Conserved hypothetical protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | 0.694 |
Rv0998 | Rv2028c | Rv0998 | Rv2028c | Conserved hypothetical protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 0.593 |
Rv0998 | rimJ | Rv0998 | Rv0995 | Conserved hypothetical protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. | [ribosomal protein S5]-alanine N-acetyltransferase; Rv0995, (MTCI237.09), len: 203 aa. RimJ,ribosomal-protein-alanine acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa), FASTA scores: (86.0% identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047 probable ribosomal-protein-alanine acetyltransferase from Sinorhizo [...] | 0.550 |
Rv2025c | Rv2026c | Rv2025c | Rv2026c | Conserved membrane protein; Rv2025c, (MTV018.12c), len: 332 aa. Conserved transmembrane protein, involved in transport of metal ions,contains IPR002524 Cation efflux protein domain; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | 0.523 |
Rv2025c | Rv2028c | Rv2025c | Rv2028c | Conserved membrane protein; Rv2025c, (MTV018.12c), len: 332 aa. Conserved transmembrane protein, involved in transport of metal ions,contains IPR002524 Cation efflux protein domain; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 0.477 |
Rv2025c | dosT | Rv2025c | Rv2027c | Conserved membrane protein; Rv2025c, (MTV018.12c), len: 332 aa. Conserved transmembrane protein, involved in transport of metal ions,contains IPR002524 Cation efflux protein domain; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.494 |
Rv2026c | Rv0998 | Rv2026c | Rv0998 | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Conserved hypothetical protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. | 0.694 |
Rv2026c | Rv2025c | Rv2026c | Rv2025c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Conserved membrane protein; Rv2025c, (MTV018.12c), len: 332 aa. Conserved transmembrane protein, involved in transport of metal ions,contains IPR002524 Cation efflux protein domain; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.523 |
Rv2026c | Rv2028c | Rv2026c | Rv2028c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 0.664 |
Rv2026c | Rv2030c | Rv2026c | Rv2030c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | 0.522 |
Rv2026c | Rv2283 | Rv2026c | Rv2283 | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Hypothetical protein; Rv2283, (MTCY339.27c), len: 64 aa. Unknown protein; questionable ORF. | 0.643 |
Rv2026c | acg | Rv2026c | Rv2032 | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.586 |
Rv2026c | dosT | Rv2026c | Rv2027c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.944 |
Rv2026c | hspX | Rv2026c | Rv2031c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3); Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. Belongs to the small heat shock protein (HSP20) family. | 0.646 |
Rv2026c | pfkB | Rv2026c | Rv2029c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.517 |
Rv2026c | rimJ | Rv2026c | Rv0995 | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | [ribosomal protein S5]-alanine N-acetyltransferase; Rv0995, (MTCI237.09), len: 203 aa. RimJ,ribosomal-protein-alanine acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa), FASTA scores: (86.0% identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047 probable ribosomal-protein-alanine acetyltransferase from Sinorhizo [...] | 0.661 |
Rv2028c | Rv0998 | Rv2028c | Rv0998 | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved hypothetical protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. | 0.593 |
Rv2028c | Rv2025c | Rv2028c | Rv2025c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved membrane protein; Rv2025c, (MTV018.12c), len: 332 aa. Conserved transmembrane protein, involved in transport of metal ions,contains IPR002524 Cation efflux protein domain; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.477 |
Rv2028c | Rv2026c | Rv2028c | Rv2026c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | 0.664 |
Rv2028c | Rv2030c | Rv2028c | Rv2030c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | 0.986 |