node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0195 | devR | Rv0195 | Rv3133c | Rv0195, (MTV033.03), len: 211 aa. Possible two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD). | Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family); Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia. The presence of target DNA increases stability of phospho-DevR in vitro. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts [...] | 0.780 |
Rv0195 | dosT | Rv0195 | Rv2027c | Rv0195, (MTV033.03), len: 211 aa. Possible two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD). | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.749 |
Rv0195 | narL | Rv0195 | Rv0844c | Rv0195, (MTV033.03), len: 211 aa. Possible two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD). | Possible nitrate/nitrite response transcriptional regulatory protein NarL; Member of the two-component regulatory system NarS/NarL that regulates genes involved in aerobic nitrate metabolism. Upon phosphorylation by NarS, functions as a transcription regulator by direct binding to promoter regions of target genes together with DevR to regulate their expression during aerobic nitrate metabolism. | 0.712 |
Rv1364c | Rv1747 | Rv1364c | Rv1747 | Rv1364c, (MTCY02B10.28c), len: 653 aa. Possible sigma factor regulatory protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap). Also known as mursiF. | Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence; In the C-terminal section; belongs to the ABC-2 integral membrane protein family. | 0.723 |
Rv1364c | dosT | Rv1364c | Rv2027c | Rv1364c, (MTCY02B10.28c), len: 653 aa. Possible sigma factor regulatory protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap). Also known as mursiF. | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.691 |
Rv1738 | Rv2028c | Rv1738 | Rv2028c | Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al., 2008); To M.tuberculosis Rv2632c. | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 0.484 |
Rv1738 | acg | Rv1738 | Rv2032 | Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al., 2008); To M.tuberculosis Rv2632c. | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.979 |
Rv1738 | devR | Rv1738 | Rv3133c | Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al., 2008); To M.tuberculosis Rv2632c. | Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family); Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia. The presence of target DNA increases stability of phospho-DevR in vitro. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts [...] | 0.717 |
Rv1738 | dosT | Rv1738 | Rv2027c | Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al., 2008); To M.tuberculosis Rv2632c. | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.670 |
Rv1738 | hspX | Rv1738 | Rv2031c | Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al., 2008); To M.tuberculosis Rv2632c. | Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3); Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. Belongs to the small heat shock protein (HSP20) family. | 0.963 |
Rv1747 | Rv1364c | Rv1747 | Rv1364c | Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence; In the C-terminal section; belongs to the ABC-2 integral membrane protein family. | Rv1364c, (MTCY02B10.28c), len: 653 aa. Possible sigma factor regulatory protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap). Also known as mursiF. | 0.723 |
Rv1747 | acg | Rv1747 | Rv2032 | Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence; In the C-terminal section; belongs to the ABC-2 integral membrane protein family. | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.510 |
Rv1747 | dosT | Rv1747 | Rv2027c | Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence; In the C-terminal section; belongs to the ABC-2 integral membrane protein family. | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.730 |
Rv2026c | Rv2028c | Rv2026c | Rv2028c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 0.664 |
Rv2026c | acg | Rv2026c | Rv2032 | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.586 |
Rv2026c | dosT | Rv2026c | Rv2027c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Two component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), [...] | 0.944 |
Rv2026c | hspX | Rv2026c | Rv2031c | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3); Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. Belongs to the small heat shock protein (HSP20) family. | 0.646 |
Rv2028c | Rv1738 | Rv2028c | Rv1738 | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al., 2008); To M.tuberculosis Rv2632c. | 0.484 |
Rv2028c | Rv2026c | Rv2028c | Rv2026c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Rv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain. | 0.664 |
Rv2028c | acg | Rv2028c | Rv2032 | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.934 |