node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobG | cobH | Rv2064 | Rv2065 | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.998 |
cobG | cobI | Rv2064 | Rv2066 | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.998 |
cobG | mazE7 | Rv2064 | Rv2063 | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | 0.786 |
cobG | mazF7 | Rv2064 | Rv2063A | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Possible toxin MazF7; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.897 |
cobH | cobG | Rv2065 | Rv2064 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | 0.998 |
cobH | cobI | Rv2065 | Rv2066 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.999 |
cobH | mazE7 | Rv2065 | Rv2063 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | 0.772 |
cobH | mazF7 | Rv2065 | Rv2063A | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Possible toxin MazF7; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.867 |
cobI | cobG | Rv2066 | Rv2064 | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | 0.998 |
cobI | cobH | Rv2066 | Rv2065 | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.999 |
cobI | mazE7 | Rv2066 | Rv2063 | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | 0.785 |
cobI | mazF7 | Rv2066 | Rv2063A | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Possible toxin MazF7; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.792 |
mazE5 | mazE7 | Rv1943c | Rv2063 | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | 0.760 |
mazE5 | mazF6 | Rv1943c | Rv1991c | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.522 |
mazE5 | mazF9 | Rv1943c | Rv2801c | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Toxin MazF9; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene. In E.coli expression with non- cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin. Belongs to the PemK/MazF family. | 0.523 |
mazE5 | vapB18 | Rv1943c | Rv2545 | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Possible antitoxin VapB18; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC18. | 0.803 |
mazE5 | vapB38 | Rv1943c | Rv2493 | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Possible antitoxin VapB38; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Its putative cognate toxin is VapC38. | 0.653 |
mazE7 | cobG | Rv2063 | Rv2064 | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | 0.786 |
mazE7 | cobH | Rv2063 | Rv2065 | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.772 |
mazE7 | cobI | Rv2063 | Rv2066 | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.785 |