node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobB | cobD | Rv2848c | Rv2236c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.899 |
cobB | cobH | Rv2848c | Rv2065 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.997 |
cobB | cobI | Rv2848c | Rv2066 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.959 |
cobB | cobK | Rv2848c | Rv2070c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.898 |
cobB | cobL | Rv2848c | Rv2072c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.934 |
cobB | cobM | Rv2848c | Rv2071c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.940 |
cobB | cobN | Rv2848c | Rv2062c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many. | 0.982 |
cobB | cobQ1 | Rv2848c | Rv0255c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.968 |
cobB | cobS | Rv2848c | Rv2208 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. | 0.964 |
cobD | cobB | Rv2236c | Rv2848c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.899 |
cobD | cobG | Rv2236c | Rv2064 | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | 0.895 |
cobD | cobH | Rv2236c | Rv2065 | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.900 |
cobD | cobI | Rv2236c | Rv2066 | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.940 |
cobD | cobK | Rv2236c | Rv2070c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.743 |
cobD | cobL | Rv2236c | Rv2072c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.977 |
cobD | cobM | Rv2236c | Rv2071c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.835 |
cobD | cobN | Rv2236c | Rv2062c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many. | 0.946 |
cobD | cobQ1 | Rv2236c | Rv0255c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.994 |
cobD | cobS | Rv2236c | Rv2208 | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. | 0.872 |
cobG | cobD | Rv2064 | Rv2236c | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.895 |