STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mraZConserved protein; Rv2166c, (MTCY270.02), len: 143 aa. Conserved protein; shows strong similarity to several hypothetical bacterial proteins such as YLLB_BACSU P55343. Is equivalent to Mycobacterium leprae hypothetical protein ML0905 (143 aa, 92% identity) MLCB268.11c >sp|O69561|YL66_MYCLE hypothetical 16.1 KDA protein ML0905 >gi|3080482|emb|CAA18677.1|(AL022602) >gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores: ML0905|ML0905 conserved hypothetical protein (143 aa) opt: 873, E(): 3.1e-52; 92.254% identity in 142 aa overlap; YLLB_BACSU P55343 hypothetical 16.6 kDa protein (143 aa) o [...] (143 aa)    
Predicted Functional Partners:
rsmH
Conserved protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA; Belongs to the methyltransferase superfamily. RsmH family.
 
  
 0.999
Rv2164c
Rv2164c, (MTCY270.04), len: 384 aa. Probable pro-rich conserved membrane protein, equivalent to ML0907|AL022602 putative conserved membrane protein from Mycobacterium leprae (377 aa) (AL022602), FASTA scores: opt: 1495, E(): 1.7e-56, (62.217% identity in 397 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
  
 0.978
pbpB
Probable penicillin-binding membrane protein PbpB; Synthesis of cross-linked peptidoglycan from the lipid intermediates; Belongs to the transpeptidase family.
 
  
 0.951
murF
Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
  
 
 0.659
Rv1730c
Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc.
   
  
 0.654
ftsK
Possible cell division transmembrane protein FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
 
  
 0.623
ftsE
Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. Has ATPase activity.
  
  
 0.619
Rv2169c
Rv2169c, (MTV021.02c), len: 134 aa. Probable conserved transmembrane protein, with orthologs in M. leprae, ML0904 probable membrane protein (134 aa), and Streptomyces coelicolor. FASTA scores with ML0904, opt: 767, E(): 5.1e-43; 86.567% identity in 134 aa overlap. emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| (AL583920). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
    0.598
ftsX
Cell division protein FtsX; Part of the ABC transporter FtsEX involved in cellular division.
  
  
 0.598
murE
Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
  
  
 0.595
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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