node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gadB | gcvB | Rv3432c | Rv1832 | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.819 |
gadB | gdh | Rv3432c | Rv2476c | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | 0.952 |
gadB | glmS | Rv3432c | Rv3436c | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.466 |
gadB | glnA1 | Rv3432c | Rv2220 | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | Glutamine synthetase GlnA1 (glutamine synthase) (GS-I); Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Also able to use GTP. D-glutamate is a poor substrate, and DL-glutamate shows about 50% of the standard specific activity. Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion. Involved in cell wall biosynthesis via the production of the major component p [...] | 0.936 |
gadB | gltB | Rv3432c | Rv3859c | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | Glutamate synthase [NADPH] large chain; Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable gltB,ferredoxin-dependent glutamate synthase large subunit,equivalent to Q9CDD5|GLTB|ML0061 putative ferredoxin-dependent glutamate synthase from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt [...] | 0.964 |
gadB | gltD | Rv3432c | Rv3858c | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | Glutamate synthase [NADPH] small chain; Rv3858c, (MTCY01A6.10), len: 488 aa. Probable gltD,small subunit of NADH-dependent glutamate synthase,equivalent to Q9CDD4|GLTD|ML0062 NADH-dependent glutamate synthase small subunit from Mycobacterium leprae (488 aa),FASTA scores: opt: 2997, E(): 1e-166, (87.7% identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa),FASTA scores: opt: 2152, E(): 1.2e-117, (63.85% identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91, (51.75% ide [...] | 0.900 |
gcvB | gadB | Rv1832 | Rv3432c | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | 0.819 |
gcvB | gdh | Rv1832 | Rv2476c | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | 0.920 |
gcvB | glnA1 | Rv1832 | Rv2220 | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Glutamine synthetase GlnA1 (glutamine synthase) (GS-I); Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Also able to use GTP. D-glutamate is a poor substrate, and DL-glutamate shows about 50% of the standard specific activity. Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion. Involved in cell wall biosynthesis via the production of the major component p [...] | 0.919 |
gcvB | glnB | Rv1832 | Rv2919c | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Probable nitrogen regulatory protein P-II GlnB; In nitrogen-limiting conditions, when the ratio of Gln to 2- ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By si [...] | 0.449 |
gcvB | gltB | Rv1832 | Rv3859c | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Glutamate synthase [NADPH] large chain; Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable gltB,ferredoxin-dependent glutamate synthase large subunit,equivalent to Q9CDD5|GLTB|ML0061 putative ferredoxin-dependent glutamate synthase from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt [...] | 0.959 |
gcvB | gltD | Rv1832 | Rv3858c | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Glutamate synthase [NADPH] small chain; Rv3858c, (MTCY01A6.10), len: 488 aa. Probable gltD,small subunit of NADH-dependent glutamate synthase,equivalent to Q9CDD4|GLTD|ML0062 NADH-dependent glutamate synthase small subunit from Mycobacterium leprae (488 aa),FASTA scores: opt: 2997, E(): 1e-166, (87.7% identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa),FASTA scores: opt: 2152, E(): 1.2e-117, (63.85% identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91, (51.75% ide [...] | 0.812 |
gdh | gadB | Rv2476c | Rv3432c | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | 0.952 |
gdh | gcvB | Rv2476c | Rv1832 | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.920 |
gdh | glnA1 | Rv2476c | Rv2220 | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Glutamine synthetase GlnA1 (glutamine synthase) (GS-I); Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Also able to use GTP. D-glutamate is a poor substrate, and DL-glutamate shows about 50% of the standard specific activity. Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion. Involved in cell wall biosynthesis via the production of the major component p [...] | 0.967 |
gdh | gltB | Rv2476c | Rv3859c | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Glutamate synthase [NADPH] large chain; Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable gltB,ferredoxin-dependent glutamate synthase large subunit,equivalent to Q9CDD5|GLTB|ML0061 putative ferredoxin-dependent glutamate synthase from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt [...] | 0.975 |
gdh | gltD | Rv2476c | Rv3858c | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Glutamate synthase [NADPH] small chain; Rv3858c, (MTCY01A6.10), len: 488 aa. Probable gltD,small subunit of NADH-dependent glutamate synthase,equivalent to Q9CDD4|GLTD|ML0062 NADH-dependent glutamate synthase small subunit from Mycobacterium leprae (488 aa),FASTA scores: opt: 2997, E(): 1e-166, (87.7% identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa),FASTA scores: opt: 2152, E(): 1.2e-117, (63.85% identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91, (51.75% ide [...] | 0.910 |
gdh | nirB | Rv2476c | Rv0252 | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Rv0252, (MTV034.18), len: 853 aa. Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit, flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI nitrite reductase (NAD(P)H) large subunit from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0, (49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN nitrite reductase (NAD(P)H) large subunit (957 aa), FASTA scores: opt: 2902,E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reduct [...] | 0.903 |
gdh | nirD | Rv2476c | Rv0253 | Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate. | Rv0253, (MTV034.19), len: 118 aa. Probable nirD,nitrite reductase [NAD(P)H] small subunit, similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157:H7 (108 aa), FASTA scores: opt: 271, E():1.7e-12, (41.9% identity in 105 aa overlap). Associates with NIRB|Rv0252. | 0.902 |
glmS | gadB | Rv3436c | Rv3432c | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...] | 0.466 |