node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2228c | Rv2229c | Rv2228c | Rv2229c | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Conserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.996 |
Rv2228c | Rv2230c | Rv2228c | Rv2230c | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | 0.990 |
Rv2228c | Rv2478c | Rv2228c | Rv2478c | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Rv2478c, (MTV008.34c), len: 161 aa. Conserved hypothetical protein, with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 putative single-strand binding protein from Streptomyces coelicolor (199 aa), FASTA scores: opt: 246, E(): 4.5e-08,(31.5% identity in 162 aa overlap); P46390|SSB_MYCLE|ML2684|MLCB1913.20c single-strand binding protein (SSB) (helix-destabilizing protein) from Mycobacterium leprae (168 aa), FASTA scores: opt: 239, E(): 1e-07, (30.8% identity in 146 aa overlap); P18310|SSBF_ECOLI single-strand binding protein from Escherichia coli (178 aa), [...] | 0.816 |
Rv2228c | cobC | Rv2228c | Rv2231c | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Rv2231c, (MTCY427.12c), len: 364 aa. Possible cobC,aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC protein (333 aa) opt: 277, E(): 1.7e-11; 28.8% identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0% identity in 289 aa overlap), contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase, hisC, is Rv1600 (MTCY336.04c); Belongs to the class-I pyridoxal-phosphate-dependent [...] | 0.959 |
Rv2228c | cobS | Rv2228c | Rv2208 | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. | 0.962 |
Rv2228c | cobT | Rv2228c | Rv2207 | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.938 |
Rv2228c | polA | Rv2228c | Rv1629 | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.857 |
Rv2228c | ptpA | Rv2228c | Rv2234 | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase); Mediates host-pathogen interaction and interferes with vesicular trafficking in the infected macrophage. Inhibits host phagolysosomal fusion in M.tuberculosis-infected macrophages to promote bacteria survival. Dephosphorylates host VPS33B protein, which induces a block of the host phagosome maturation within macrophage cells. Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; Belongs to the low molecular weight phosphotyrosine prot [...] | 0.815 |
Rv2228c | rnhB | Rv2228c | Rv2902c | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Probable ribonuclease HII protein RnhB (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.954 |
Rv2228c | ssb | Rv2228c | Rv0054 | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | Rv0054, (MTCY21D4.17), len: 164 aa. ssb,single-strand binding protein (see Mizrahi & Andersen 1998), highly similar to others. Belongs to the SSB family. | 0.839 |
Rv2229c | Rv2228c | Rv2229c | Rv2228c | Conserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | 0.996 |
Rv2229c | Rv2230c | Rv2229c | Rv2230c | Conserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | 0.994 |
Rv2229c | cobC | Rv2229c | Rv2231c | Conserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Rv2231c, (MTCY427.12c), len: 364 aa. Possible cobC,aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC protein (333 aa) opt: 277, E(): 1.7e-11; 28.8% identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0% identity in 289 aa overlap), contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase, hisC, is Rv1600 (MTCY336.04c); Belongs to the class-I pyridoxal-phosphate-dependent [...] | 0.984 |
Rv2229c | ptpA | Rv2229c | Rv2234 | Conserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase); Mediates host-pathogen interaction and interferes with vesicular trafficking in the infected macrophage. Inhibits host phagolysosomal fusion in M.tuberculosis-infected macrophages to promote bacteria survival. Dephosphorylates host VPS33B protein, which induces a block of the host phagosome maturation within macrophage cells. Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; Belongs to the low molecular weight phosphotyrosine prot [...] | 0.754 |
Rv2230c | Rv2228c | Rv2230c | Rv2228c | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | 0.990 |
Rv2230c | Rv2229c | Rv2230c | Rv2229c | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | Conserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.994 |
Rv2230c | cobC | Rv2230c | Rv2231c | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | Rv2231c, (MTCY427.12c), len: 364 aa. Possible cobC,aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC protein (333 aa) opt: 277, E(): 1.7e-11; 28.8% identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0% identity in 289 aa overlap), contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase, hisC, is Rv1600 (MTCY336.04c); Belongs to the class-I pyridoxal-phosphate-dependent [...] | 0.996 |
Rv2230c | polA | Rv2230c | Rv1629 | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.619 |
Rv2230c | ptpA | Rv2230c | Rv2234 | Conserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P534 [...] | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase); Mediates host-pathogen interaction and interferes with vesicular trafficking in the infected macrophage. Inhibits host phagolysosomal fusion in M.tuberculosis-infected macrophages to promote bacteria survival. Dephosphorylates host VPS33B protein, which induces a block of the host phagosome maturation within macrophage cells. Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; Belongs to the low molecular weight phosphotyrosine prot [...] | 0.766 |
Rv2478c | Rv2228c | Rv2478c | Rv2228c | Rv2478c, (MTV008.34c), len: 161 aa. Conserved hypothetical protein, with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 putative single-strand binding protein from Streptomyces coelicolor (199 aa), FASTA scores: opt: 246, E(): 4.5e-08,(31.5% identity in 162 aa overlap); P46390|SSB_MYCLE|ML2684|MLCB1913.20c single-strand binding protein (SSB) (helix-destabilizing protein) from Mycobacterium leprae (168 aa), FASTA scores: opt: 239, E(): 1e-07, (30.8% identity in 146 aa overlap); P18310|SSBF_ECOLI single-strand binding protein from Escherichia coli (178 aa), [...] | Multifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. | 0.816 |