STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2300cConserved protein; Rv2300c, (MTCY339.09), len: 310 aa (start uncertain). Conserved protein, similar to others e.g. Q9RXY2|DR0172 conserved hypothetical protein from Deinococcus radiodurans (271 aa), FASTA scores: opt: 306,E(): 1.3e-12, (34.6% identity in 229 aa overlap); Q9HZH1|PA3037 hypothetical protein from Pseudomonas aeruginosa (288 aa), FASTA scores: opt: 248, E(): 7.9e-09,(31.5% identity in 238 aa overlap); Q9PDL8|XF1361 hypothetical protein from Xylella fastidiosa (279 aa),FASTA scores: opt: 236, E(): 4.6e-08, (29.7% identity in 249 aa overlap); U70053|XCU70053_3 GumP protein f [...] (310 aa)    
Predicted Functional Partners:
Rv0331
Rv0331, (MTCY63.36), len: 388 aa. Possible dehydrogenase/reductase, similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhizobium loti (377 aa); NP_147681.1 predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% identity in 348 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
   
 0.651
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
  
    0.594
cut2
Probable cutinase Cut2; Rv2301, (MTCY339.08c), len: 230 aa. Probable cut2 (alternate gene name: cfp25), cutinase, highly similar to others from Mycobacteria tuberculosis e.g. MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa), FASTA scores: opt: 569, E(): 2.3e-27, (45.3% identity in 223 aa overlap); MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217 aa), FASTA scores: opt: 383, E(): 3.4e-16 (42.9% identity in 217 aa overlap); O69691|Rv3724|MTV025.072 putative cutinase precursor (187 aa), FASTA scores: opt: 248, E(): 4.3e-08, (41.85% identity in 172 aa overlap); etc. Also similar to few others [...]
  
    0.572
Rv1752
Rv1752, (MTCY28.15), len: 149 aa. Conserved hypothetical protein, similar to C-terminal half of Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase from Canis familiaris (335 aa), FASTA score, opt: 168, E(): 0.00015,(31.3% identity in 112 aa overlap).
 
    0.509
Rv2337c
Hypothetical protein; Rv2337c, (MTCY98.06c), len: 372 aa. Hypothetical unknown protein, sharing some similarity with Q9RI33|SCJ12.27c hypothetical 37.2 KDA protein from Streptomyces coelicolor (335 aa), blast scores: 134 and 46,(28% and 33% identity, 52% and 44% positive); FASTA scores: opt: 176, E(): 0.00042, (31.95% identity in 355 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
 
    0.479
pks12
Polyketide synthase Pks12; Rv2048c, (MTV018.35c), len: 4151 aa. Pks12,polyketide synthase similar to many. Contains 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 Beta-ketoacyl synthases active site, and PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. Nucleotide position 2297976 in the genome sequence has been corrected, G:A resulting in S3004L.
 
 
 
 0.452
Rv2777c
Rv2777c, (MTV002.42c), len: 356 aa. Conserved hypothetical protein, highly similar (but longer in N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from Streptomyces coelicolor (296 aa), FASTA scores: opt: 980,E(): 6.8e-57, (51.25% identity in 281 aa overlap); and Q9HYS0|PA3325 from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 816, E(): 4e-46, (43.75% identity in 288 aa overlap); and similar (but longer in N-terminus) to other hypothetical proteins e.g. Q9I3H1|PA1542 from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 234, E(): 6.3e-08,(31.8% identity in 258 aa overlap) [...]
  
     0.446
pks1
Probable polyketide synthase Pks1; May play a role in phthiocerol biosynthesis.
 
 
 0.439
ybeY
Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
   
 
 0.420
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
   
 
 0.419
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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