STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Coexpression
Experiments
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[Homology]
Score
plcBMembrane-associated phospholipase C 2 PlcB; Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity. (512 aa)    
Predicted Functional Partners:
plcC
Rv2349c, (MT2414, MTCY98.18c), len: 508 aa. Probable plcC, phospolipase C 3 (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C precursor from Pseudomonas aeruginosa (692 aa), FASTA scores: opt: 1013, E(): 9.3e-54, (38.85% identity in 525 aa overlap); P06200|PHLC_PSEAE hemolytic phospholipase C precursor from Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 630, E(): 1.5e-30, (35.15% identity in 535 aa overlap); Q9S816|T12J13.18|T21P5.4 putative phospholipase from Arabidopsis thaliana (Mouse-ear cr [...]
 
 
0.991
plcA
Membrane-associated phospholipase C 1 PlcA (MTP40 antigen); Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity; Belongs to the bacterial phospholipase C family.
 
 
0.952
plcD
Rv1755c, (MT1799, MTCY28.21c), len: 280 aa. Probable plcD, phospholipase C 4 (fragment) (see citations below),highly similar to C-terminus of other phospholipases e.g. CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 from Mycobacterium tuberculosis (512 aa), FASTA score: (71.1% identity in 284 aa overlap); etc. Note that this ORF has been interrupted by insertion of IS6110 element. Belongs to the bacterial phospholipase C family.
 
 
0.908
sapM
Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase); Virulence factor that plays an important role in blocking phagosome-lysosome fusion and thus participates in the intracellular survival of the pathogen. Acts as a phosphatase that dephosphorylates phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents. Therefore, SapM eliminates PI3P from the phagosomal membrane by catalyzing its hydrolysis, and thus contributes to inhibition of phagosome maturation. Also interf [...]
    
  0.902
psd
Possible phosphatidylserine decarboxylase Psd (PS decarboxylase); Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
   
 
  0.900
impA
Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria.
   
 
  0.900
pgsA2
Putative cardiolipin synthase; May catalyze the biosynthesis of cardiolipin from phosphatidylglycerol (PG) and CDP-diacylglycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
   
 
  0.900
dagK
Diacylglycerol kinase; Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is involved in the biosynthesis of phosphatidylinositol mannosides (PIMs), probably via a role in the biosynthesis of phosphatidylinositol (PI), a PIM precursor, which is derived from phosphatidic acid (By similarity); Belongs to the diacylglycerol/lipid kinase family.
   
 
  0.900
suhB
Inositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol- 6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency.
     
  0.900
Rv1279
Rv1279, (MTCY50.03c), len: 528 aa. Probable dehydrogenase, FAD flavoprotein GMC oxidoreductase, similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa), FASTA scores, opt: 1047,E(): 0, (37.7% identity in 541 aa overlap). Similar to Rv0697 putative Mycobacterium tuberculosis GMC oxidoreductase. Contains PS00623 GMC oxidoreductases signature 1, and PS00624 GMC oxidoreductases signature 2. Belongs to the GMC oxidoreductases family.
   
 
  0.805
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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