node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1460 | furA | Rv1460 | Rv1909c | Rv1460, (MTV007.07), len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 - 89. Start changed since original submission. | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | 0.480 |
Rv1460 | zur | Rv1460 | Rv2359 | Rv1460, (MTV007.07), len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 - 89. Start changed since original submission. | Probable zinc uptake regulation protein Zur; Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc; Belongs to the Fur family. | 0.847 |
furA | Rv1460 | Rv1909c | Rv1460 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | Rv1460, (MTV007.07), len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 - 89. Start changed since original submission. | 0.480 |
furA | ideR | Rv1909c | Rv2711 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. | 0.672 |
furA | rpoA | Rv1909c | Rv3457c | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.696 |
furA | rpoB | Rv1909c | Rv0667 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.615 |
furA | rpoC | Rv1909c | Rv0668 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.487 |
furA | rpoZ | Rv1909c | Rv1390 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.489 |
furA | sigA | Rv1909c | Rv2703 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | RNA polymerase sigma factor SigA (sigma-A); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (Probable); Belongs to the sigma-70 factor family. RpoD/SigA subfamily. | 0.587 |
furA | sigB | Rv1909c | Rv2710 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. A non-essential principal sigma factor that responds to cell envelope stress and hypoxia. Controls a regulon of about 40 genes, with another 100 genes expression being altered during SDS stress and about 50 gene being altered during diamide (oxidative) stress. | 0.589 |
furA | zur | Rv1909c | Rv2359 | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | Probable zinc uptake regulation protein Zur; Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc; Belongs to the Fur family. | 0.900 |
ideR | furA | Rv2711 | Rv1909c | Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | 0.672 |
ideR | rpoB | Rv2711 | Rv0667 | Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.502 |
ideR | sigB | Rv2711 | Rv2710 | Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. A non-essential principal sigma factor that responds to cell envelope stress and hypoxia. Controls a regulon of about 40 genes, with another 100 genes expression being altered during SDS stress and about 50 gene being altered during diamide (oxidative) stress. | 0.943 |
ideR | smtB | Rv2711 | Rv2358 | Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. | Probable transcriptional regulatory protein SmtB (probably ArsR-family); Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of zinc. Could act as the metal sensor that controls the expression of zur in response to zinc availability. | 0.413 |
ideR | zur | Rv2711 | Rv2359 | Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. | Probable zinc uptake regulation protein Zur; Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc; Belongs to the Fur family. | 0.877 |
rpoA | furA | Rv3457c | Rv1909c | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Ferric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; Belongs to the Fur family. | 0.696 |
rpoA | rpoB | Rv3457c | Rv0667 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
rpoA | rpoC | Rv3457c | Rv0668 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
rpoA | rpoZ | Rv3457c | Rv1390 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.999 |