STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
cysHProbable phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (254 aa)    
Predicted Functional Partners:
cysN
Sulfate adenylyltransferase subunit 1; ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity; In the C-terminal section; belongs to the APS kinase family.
 0.999
sirA
Ferredoxin-dependent sulfite reductase SirA; Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
 0.999
che1
Ferrochelatase Che1; Rv2393, (MTCY253.28c), len: 281 aa. Che1,ferrochelatase (See Pinto et al., 2007). Conserved protein,with some similarity to Q9L2E8|SC7A8.10c putative secreted protein from Streptomyces coelicolor (274 aa), FASTA scores: opt: 407, E(): 2.8e-18, (37% identity in 246 aa overlap); CAC38793|SCI39.05 Conserved hypothetical protein from Streptomyces coelicolor (305 aa), FASTA scores: opt: 394, E(): 2e-17, (35.0% identity in 251 aa overlap); AAK44492|MT0272 Chalcone/stilbene synthase family protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 350, E(): 9.2e [...]
 
  
 0.990
cysQ
Monophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. [...]
  
 
 0.968
ggtB
Rv2394, (MTCY253.27c), len: 643 aa. Probable ggtB,gamma-glutamyltranspeptidase precursor, similar to many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa), FASTA scores: opt: 943, E(): 7.5e-47, (40.0% identity in 597 aa overlap); O69935|SC3C8.26 from Streptomyces coelicolor (603 aa), FASTA scores: opt: 822, E(): 7.2e-40, (33.6% identity in 622 aa overlap); P54422|GGT_BACSU from Bacillus subtilis (587 aa) FASTA scores: opt: 491, E(): 8.2e-21, (33.4% identity in 574 aa overlap); etc. Has potential signal peptide and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).
  
  
 0.957
cysD
Rv1285, (MTCY373.04), len: 332 aa. Probable cysD,sulfate adenylyltransferase subunit 2 (see Wooff et al.,2002), homology suggests start site at aa 24 or 28, similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate transferase subunit 2 from Escherichia coli (302 aa), FASTA score: opt: 973, E():0, (52.5% identity in 303 aa overlap). Also similar to Mycobacterium tuberculosis Rv2392,3'-phosphoadenylylsulfate reductase. Belongs to the PAPS reductase family. CYSD subfamily. Thought to be differentially expressed within host cells (see Triccas et al., 1999).
 
   
 0.934
cysG
Rv2847c, (MTCY24A1.10), len: 405 aa. Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-III c-methyltransferase, precorrin-2 oxidase and ferrochelatase. C-terminus highly similar to many uroporphyrin-III c-methyltransferases e.g. Q51720|COBA uroporphyrinogen III methyltransferase from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): [...]
 
  
 0.932
cysA2
Putative thiosulfate sulfurtransferase; May be a sulfotransferase involved in the formation of thiosulfate.
  
 
 0.926
sseB
Rv2291, (MTCY339.19c), len: 284 aa. Probable sseB,thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; Smith-Waterman score: 765; 46.9% identity in 286 aa overlap, similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): 1e-23, (35.1% identity in 265 aa overlap).
  
 
 0.909
sseA
Rv3283, (MTCY71.23), len: 297 aa. Probable sseA,thiosulfate sulfurtransferase, equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 putative thiosulfate sulfurtransferase SSEA from Mycobacterium leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108,(83.45% identity in 296 aa overlap). Also highly similar to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86% identity in 273 aa overlap); P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25% [...]
  
 
 0.909
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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