node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0484c | Rv0712 | Rv0484c | Rv0712 | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | 0.870 |
Rv0484c | Rv1730c | Rv0484c | Rv1730c | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | 0.753 |
Rv0484c | Rv3205c | Rv0484c | Rv3205c | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | Conserved protein; Rv3205c, (MTCY07D11.21), len: 292 aa. Conserved protein, highly similar to Q9CCG7|ML0818 hypothetical protein from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.872 |
Rv0484c | Rv3762c | Rv0484c | Rv3762c | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | Possible hydrolase; Rv3762c, (MTV025.110c), len: 626 aa. Possible hydrolase, highly similar to hypothetical proteins and beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA protein from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 hypothetical 73.2 KDA protein from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113, (46.9% identity in 631 aa overlap); Q9A824|CC1540 metallo-beta-lactamase family protein from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E [...] | 0.870 |
Rv0484c | espR | Rv0484c | Rv3849 | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | 0.437 |
Rv0484c | nrnA | Rv0484c | Rv2837c | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | Conserved protein; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. | 0.870 |
Rv0484c | rnz | Rv0484c | Rv2407 | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.870 |
Rv0712 | Rv0484c | Rv0712 | Rv0484c | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | 0.870 |
Rv0712 | Rv1730c | Rv0712 | Rv1730c | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | 0.559 |
Rv0712 | Rv3205c | Rv0712 | Rv3205c | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | Conserved protein; Rv3205c, (MTCY07D11.21), len: 292 aa. Conserved protein, highly similar to Q9CCG7|ML0818 hypothetical protein from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.870 |
Rv0712 | Rv3762c | Rv0712 | Rv3762c | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | Possible hydrolase; Rv3762c, (MTV025.110c), len: 626 aa. Possible hydrolase, highly similar to hypothetical proteins and beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA protein from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 hypothetical 73.2 KDA protein from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113, (46.9% identity in 631 aa overlap); Q9A824|CC1540 metallo-beta-lactamase family protein from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E [...] | 0.889 |
Rv0712 | nrnA | Rv0712 | Rv2837c | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | Conserved protein; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. | 0.807 |
Rv0712 | rnz | Rv0712 | Rv2407 | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.891 |
Rv1730c | Rv0484c | Rv1730c | Rv0484c | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity,to bacterial YDFG homologs. | 0.753 |
Rv1730c | Rv0712 | Rv1730c | Rv0712 | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. | 0.559 |
Rv1730c | Rv3205c | Rv1730c | Rv3205c | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | Conserved protein; Rv3205c, (MTCY07D11.21), len: 292 aa. Conserved protein, highly similar to Q9CCG7|ML0818 hypothetical protein from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.753 |
Rv1730c | Rv3762c | Rv1730c | Rv3762c | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | Possible hydrolase; Rv3762c, (MTV025.110c), len: 626 aa. Possible hydrolase, highly similar to hypothetical proteins and beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA protein from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 hypothetical 73.2 KDA protein from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113, (46.9% identity in 631 aa overlap); Q9A824|CC1540 metallo-beta-lactamase family protein from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E [...] | 0.661 |
Rv1730c | nrnA | Rv1730c | Rv2837c | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | Conserved protein; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. | 0.545 |
Rv1730c | rnz | Rv1730c | Rv2407 | Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc. | Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.673 |
Rv2406c | rnz | Rv2406c | Rv2407 | Conserved protein; Rv2406c, (MTCY253.14), len: 142 aa. Conserved protein. C-terminal region is identical with many CBS domain protein e.g. AAK46774|MT2478 CBS domain protein from Mycobacterium tuberculosis strain CDC1551 (aa 47-142),FASTA scores: opt: 594, E(): 1.9e-30, (98.97% identity in 97 aa overlap); etc. Also similar to other hypothetical proteins e.g. AAK24594|CC2626 CBS domain protein from Caulobacter crescentus (157 aa), FASTA scores: opt: 377,E(): 8.3e-17, (42.55% identity in 141 aa overlap); BAB47826|MLR0188 from Rhizobium loti; etc. | Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.548 |