node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1190 | Rv1359 | Rv1190 | Rv1359 | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | 0.791 |
Rv1190 | Rv1725c | Rv1190 | Rv1725c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Conserved hypothetical protein; Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from butyrivibrio fibrisolvens, (108 aa), FASTA scores: opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 aa). | 0.829 |
Rv1190 | Rv1931c | Rv1190 | Rv1931c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Probable transcriptional regulatory protein; Controls the expression of genes important for virulence. | 0.863 |
Rv1190 | Rv2488c | Rv1190 | Rv2488c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Rv2488c, (MTV008.44c), len: 1137 aa. Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory protein [...] | 0.847 |
Rv1190 | Rv3736 | Rv1190 | Rv3736 | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Transcriptional regulatory protein (probably AraC/XylS-family); Rv3736, (MTV025.084), len: 353 aa. Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 hypothetical 35.4 KDA protein from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438,E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 probable transcriptional regulator from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395,E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 probable transcriptional regulator from P [...] | 0.830 |
Rv1190 | cmr | Rv1190 | Rv1675c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.851 |
Rv1190 | embR | Rv1190 | Rv1267c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Probable transcriptional regulatory protein EmbR; Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities; Belongs to the AfsR/DnrI/RedD regulatory family. | 0.838 |
Rv1190 | kdpE | Rv1190 | Rv1027c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Probable transcriptional regulatory protein KdpE; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Upon phosphorylation by KdpD, functions as a transcription regulator by direct binding to promoter regions of target genes to positively regulate their expression. | 0.801 |
Rv1190 | sigI | Rv1190 | Rv1189 | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). | 0.971 |
Rv1190 | tcrA | Rv1190 | Rv0602c | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | Two component DNA binding transcriptional regulatory protein TcrA; Member of the three-protein two-component system HK1/HK2/TcrA. | 0.801 |
Rv1359 | Rv1190 | Rv1359 | Rv1190 | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap). | 0.791 |
Rv1359 | Rv1725c | Rv1359 | Rv1725c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Conserved hypothetical protein; Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from butyrivibrio fibrisolvens, (108 aa), FASTA scores: opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 aa). | 0.827 |
Rv1359 | Rv1931c | Rv1359 | Rv1931c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein; Controls the expression of genes important for virulence. | 0.855 |
Rv1359 | Rv2488c | Rv1359 | Rv2488c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Rv2488c, (MTV008.44c), len: 1137 aa. Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory protein [...] | 0.846 |
Rv1359 | Rv3736 | Rv1359 | Rv3736 | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Transcriptional regulatory protein (probably AraC/XylS-family); Rv3736, (MTV025.084), len: 353 aa. Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 hypothetical 35.4 KDA protein from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438,E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 probable transcriptional regulator from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395,E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 probable transcriptional regulator from P [...] | 0.846 |
Rv1359 | cmr | Rv1359 | Rv1675c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.898 |
Rv1359 | embR | Rv1359 | Rv1267c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein EmbR; Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities; Belongs to the AfsR/DnrI/RedD regulatory family. | 0.833 |
Rv1359 | kdpE | Rv1359 | Rv1027c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein KdpE; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Upon phosphorylation by KdpD, functions as a transcription regulator by direct binding to promoter regions of target genes to positively regulate their expression. | 0.845 |
Rv1359 | sigI | Rv1359 | Rv1189 | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). | 0.821 |
Rv1359 | tcrA | Rv1359 | Rv0602c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Two component DNA binding transcriptional regulatory protein TcrA; Member of the three-protein two-component system HK1/HK2/TcrA. | 0.858 |