STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2567Rv2567, (MTCY227.34c, MTCY9C4.01c), len: 884 aa. Conserved hypothetical ala-, leu-rich protein, equivalent to O53121|ML2679|MLCB1913.13 hypothetical protein from Mycobacterium leprae (893 aa), FASTA scores: opt: 4326,E(): 0, (75.2% identity in 883 aa overlap); and similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 hypothetical 61.8 KDA protein from Mycobacterium leprae (561 aa), FASTA scores: opt: 758, E(): 1.2e-38, (32.2% identity in 537 aa overlap). Also similar to others e.g. Q9HUN7|PA4927 hypothetical protein from Pseudomonas aeruginosa (830 aa), FASTA scores: opt: 1 [...] (884 aa)    
Predicted Functional Partners:
Rv2566
Long conserved protein; Rv2566, (MTCY9C4.02c), len: 1140 aa. Long conserved protein, equivalent to O53120|ML2678 or MLCB1913.12 hypothetical protein from Mycobacterium leprae (1000 aa),FASTA scores: opt: 760, E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA protein (fragment) from Mycobacterium leprae (644 aa),FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,(52.4% [...]
 
  
 0.979
Rv2569c
Rv2569c, (MTCY227.32), len: 314 aa. Conserved hypothetical protein, equivalent to Q9CCT2|ML0508 hypothetical protein from Mycobacterium leprae (313 aa),FASTA scores: opt: 1723, E(): 1.9e-95, (84.4% identity in 301 aa overlap); and some similarity with Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39 hypothetical 31.1 KDA protein from Mycobacterium leprae (279 aa), FASTA scores: opt: 305, E(): 4.5e-11, (33.0% identity in 300 aa overlap). Also similar to to other hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas aeruginosa (311 aa), FASTA scores: opt: 704, E(): 8.7e-35,(39.7% ide [...]
 
  
 0.914
Rv2409c
Conserved protein; Rv2409c, (MTCY253.11), len: 279 aa. Conserved protein, equivalent to Q49757|YP69_MYCLE|G466976|B1937_F2_39 hypothetical protein from Mycobacterium leprae (279 aa), FASTA scores: opt: 1564, E(): 4.6e-95, (82.1% identity in 279 aa overlap). Also similar to others e.g. Q9RSX6|DR1993 from Deinococcus radiodurans (274 aa), FASTA scores: opt: 494, E(): 4e-25,(35.1% identity in 282 aa overlap); BAB49898|Mll2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 382, E(): 8.9e-18, (29.75% identity in 269 aa overlap); Q9I305|PA1732 from Pseudomonas aerugino [...]
 
  
 0.840
Rv2568c
Rv2568c, (MTCY227.33), len: 341 aa. Conserved hypothetical protein, highly similar (but longer 60 aa) to Q98E75|MLR4376 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (308 aa), FASTA scores: opt: 566, E(): 4.1e-29, (40.2% identity in 291 aa overlap).
 
     0.815
Rv2565
Conserved protein; Rv2565, (MTCY9C4.03c), len: 583 aa. Conserved protein, similar in part to Q9A6C3|CC2171 hypothetical protein from Caulobacter crescentus (610 aa), FASTA scores: opt: 765, E(): 2.8e-37, (32.15% identity in 575 aa overlap). C-terminus also highly similar to various bacterial proteins e.g. O34731|YLBK_BACSU hypothetical 28.3 KDA protein from Bacillus subtilis (260 aa), FASTA scores: opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa overlap); CAC45997|SMC01003 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa),FASTA scores: opt: 352 [...]
       0.763
Rv2560
Rv2560, (MTCY9C4.08c), len: 325 aa. Probable transmembrane protein, pro-, gly-rich protein.
       0.609
Rv1673c
Rv1673c, (MTV047.08c), len: 310 aa. Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap).
 
  
 0.580
Rv2410c
Conserved protein; Rv2410c, (MTCY253.10), len: 325 aa. Conserved protein, equivalent to Q49770|CAC30114|ML0606 conserved hypothetical protein from Mycobacterium leprae (325 aa),FASTA scores: opt: 1928, E(): 3.5e-117, (90.75% identity in 325 aa overlap). Also some similarity with other hypothetical proteins e.g. Q9RST2|DR2041 conserved hypothetical protein from Deinococcus radiodurans (316 aa),FASTA scores: opt: 329, E(): 5.3e-14, (32.4% identity in 318 aa overlap); C-terminus of Q9HUN7|PA4927 hypothetical protein from Pseudomonas aeruginosa (830 aa), FASTA scores: opt: 297, E(): 1.5e-1 [...]
 
  
0.570
Rv2411c
Rv2411c, (MTCY253.09c), len: 551 aa. Hypothetical protein, highly similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 hypothetical 61.8 KDA protein from Mycobacterium leprae (561 aa), FASTA scores, opt: 3163, E(): 4.1e-178, (87.35% identity in 554 aa overlap). Also highly similar, except in N-terminus, to others e.g. Q55587|Y335_SYNY3|SLL0335 hypothetical protein from Synechocystis sp. strain PCC 6803 (481 aa), FASTA scores: opt: 1620, E(): 1.2e-87, (52.8% identity in 468 aa overlap); Q9I307|PA1730 hypothetical protein from Pseudomonas aeruginosa (470 aa), FASTA scores: o [...]
 
  
0.520
ligD
Multifunctional non-homologous end joining DNA repair protein LigD; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA stra [...]
  
    0.506
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (30%) [HD]