node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1000c | Rv2573 | Rv1000c | Rv2573 | Rv1000c, len: 205 aa. Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa), FASTA scores: E(): 2.1e-45, (56.8% identity); 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa), FASTA scores: E(): 3.4e-14, (38.55% identity); and similar in C-terminus to other hypothetical proteins. Note that re [...] | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.682 |
Rv2573 | Rv1000c | Rv2573 | Rv1000c | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Rv1000c, len: 205 aa. Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa), FASTA scores: E(): 2.1e-45, (56.8% identity); 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa), FASTA scores: E(): 3.4e-14, (38.55% identity); and similar in C-terminus to other hypothetical proteins. Note that re [...] | 0.682 |
Rv2573 | Rv2574 | Rv2573 | Rv2574 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap). | 0.742 |
Rv2573 | Rv2575 | Rv2573 | Rv2575 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallo [...] | 0.811 |
Rv2573 | aspS | Rv2573 | Rv2572c | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | 0.745 |
Rv2573 | coaE | Rv2573 | Rv1631 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase); Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Can also use dATP, with lower efficiency, but cannot use GTP, dGTP or CTP ; In the C-terminal section; belongs to the UPF0157 (GrpB) family. | 0.713 |
Rv2573 | pafC | Rv2573 | Rv2095c | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Proteasome accessory factor C PafC; Part of the pafABC operon, but PafC does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to reactive nitrogen intermediates (RNI) in vitro. | 0.554 |
Rv2573 | panB | Rv2573 | Rv2225 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. | 0.930 |
Rv2573 | panC | Rv2573 | Rv3602c | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. | 0.933 |
Rv2573 | recB | Rv2573 | Rv0630c | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | RecBCD enzyme subunit RecB; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] | 0.527 |
Rv2573 | ribA1 | Rv2573 | Rv1940 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Rv1940, (MTCY09F9.24c), len: 353 aa. Probable ribA1,Riboflavin biosynthesis protein, similar to GCH2_BACSU|P17620 gtp cyclohydrolase II (398 aa), FASTA scores: opt: 682, E(): 0, (37.7% identity in 363 aa overlap), also similar to Rv1415|MTCY21B4.33|ribA2 (428 aa) (45.4% identity in 368 aa overlap). Note that previously known as ribA; In the N-terminal section; belongs to the DHBP synthase family. | 0.544 |
Rv2574 | Rv2573 | Rv2574 | Rv2573 | Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap). | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.742 |
Rv2574 | Rv2575 | Rv2574 | Rv2575 | Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap). | Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallo [...] | 0.697 |
Rv2574 | aspS | Rv2574 | Rv2572c | Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap). | Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | 0.433 |
Rv2575 | Rv2573 | Rv2575 | Rv2573 | Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallo [...] | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.811 |
Rv2575 | Rv2574 | Rv2575 | Rv2574 | Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallo [...] | Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap). | 0.697 |
Rv2575 | aspS | Rv2575 | Rv2572c | Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallo [...] | Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | 0.518 |
aspS | Rv2573 | Rv2572c | Rv2573 | Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.745 |
aspS | Rv2574 | Rv2572c | Rv2574 | Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap). | 0.433 |
aspS | Rv2575 | Rv2572c | Rv2575 | Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallo [...] | 0.518 |