STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2597Probable membrane protein; Rv2597, (MTCY227.04c), len: 206 aa. Probable membrane protein. Predicted to be an outer membrane protein (See Song et al., 2008). (206 aa)    
Predicted Functional Partners:
Rv2598
Rv2598, (MTCY227.03c), len: 164 aa. Conserved hypothetical protein, showing similarity with hypothetical proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c (185 aa), FASTA scores: opt: 197, E(): 3.5e-06, (34.75% identity in 167 aa overlap); and Q9L088|SCC24.29c (172 aa),FASTA scores: opt: 149, E(): 0.0053, (37.65% identity in 146 aa overlap). Equivalent to AAK46988 from Mycobacterium tuberculosis strain CDC1551 (154 aa) but longer 10 aa.
 
    0.976
Rv2600
Rv2600, (MTCY277.01c, MTV001.01), len: 133 aa. Probable conserved integral membrane protein, equivalent (but shorter 18 aa) to Q9K537|YQ00_MYCPA hypothetical protein RV2600 homolog from Mycobacterium paratuberculosis (151 aa), FASTA scores: opt: 543, E(): 4.2e-28, (62.9% identity in 132 aa overlap). Also some similarity with other hypothetical or membrane proteins e.g. Q9L090|SCC24.27c putative integral membrane protein from Streptomyces coelicolor (146 aa), FASTA scores: opt: 241,E(): 8.7e-09, (34.8% identity in 135 aa overlap); O58487|PH0773 hypothetical 15.0 KDA protein from Pyrococ [...]
 
    0.946
speE
Polyamine aminopropyltransferase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
 
    0.905
Rv2599
Rv2599, (MTCY227.02c), len: 143 aa. Probable conserved membrane protein, equivalent to Q9K536|2599 hypothetical 15.0 KDA protein (fragment) from Mycobacterium paratuberculosis (143 aa), FASTA scores: opt: 691, E(): 1.7e-33, (68.55% identity in 143 aa overlap). Shows weak similarity with Q9L089|SCC24.28c putative lipoprotein from Streptomyces coelicolor (131 aa), FASTA scores: opt: 130,E(): 0.52, (26.45% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Predicted to be an outer membrane protein (See Song et al., 2008).
  
    0.875
Rv1006
Unknown protein; Rv1006, (MTCI237.23), len: 567 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
  
    0.702
Rv1868
Rv1868, (MTCY359.05c), len: 699 aa. Conserved hypothetical protein, similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314,E(): 9.9e-12, (35.2% identity in 213 aa overlap); MLCB2052.17, and MLCB2052.16. Also similar to M. tuberculosis hypothetical protein Rv2047c.
  
     0.685
Rv1435c
Rv1435c, (MTCY493.19), len: 202 aa. Probable conserved Pro-, Gly-, Val-rich secreted protein (see citation below) with a N-terminal signal sequence. Similar at C-terminus to AF017099|AF017099_1 Mycobacterium tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E(): 2.3e-17, (97.7% identity in 86 aa overlap). Shows some similarity to N-terminus of CPN_DROME|Q02910 calphotin. Drosophila melanogaster (865 aa), FASTA scores: opt: 266,E(): 2.5e-05, (37.2% identity in 191 aa overlap). Contains at least five 7 aa imperfect repeats. Also shows similarity to other Mycobacterium tuberculosis prote [...]
  
     0.640
Rv2047c
Rv2047c, (MTV018.34c), len: 854 aa. Conserved hypothetical protein, similar to many. Contains IPR016040 NAD(P)-binding domain at N-terminus; Belongs to the PEP-utilizing enzyme family.
  
     0.597
vapB40
Possible antitoxin VapB40; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC40. Upon expression in E.coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9; Belongs to the VapB family.
       0.590
vapC40
Possible toxin VapC40. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Its cognate antitoxin is VapB40.
  
    0.590
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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