node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysQ | glpX | Rv2131c | Rv1099c | Monophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. [...] | Fructose 1,6-bisphosphatase GlpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate. | 0.595 |
cysQ | impA | Rv2131c | Rv1604 | Monophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. [...] | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.565 |
cysQ | suhB | Rv2131c | Rv2701c | Monophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. [...] | Inositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol- 6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency. | 0.724 |
fmu | impA | Rv1407 | Rv1604 | Probable Fmu protein (sun protein); May act as RNA methyltransferase. | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.638 |
fmu | suhB | Rv1407 | Rv2701c | Probable Fmu protein (sun protein); May act as RNA methyltransferase. | Inositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol- 6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency. | 0.633 |
glpX | cysQ | Rv1099c | Rv2131c | Fructose 1,6-bisphosphatase GlpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate. | Monophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. [...] | 0.595 |
glpX | impA | Rv1099c | Rv1604 | Fructose 1,6-bisphosphatase GlpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate. | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.727 |
glpX | suhB | Rv1099c | Rv2701c | Fructose 1,6-bisphosphatase GlpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate. | Inositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol- 6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency. | 0.611 |
impA | cysQ | Rv1604 | Rv2131c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Monophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. [...] | 0.565 |
impA | fmu | Rv1604 | Rv1407 | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Probable Fmu protein (sun protein); May act as RNA methyltransferase. | 0.638 |
impA | glpX | Rv1604 | Rv1099c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Fructose 1,6-bisphosphatase GlpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate. | 0.727 |
impA | ino1 | Rv1604 | Rv0046c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Inositol-3-phosphate synthase; Catalyzes the conversion of glucose 6-phosphate to 1D-myo- inositol 3-phosphate; Belongs to the myo-inositol 1-phosphate synthase family. | 0.983 |
impA | plcA | Rv1604 | Rv2351c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Membrane-associated phospholipase C 1 PlcA (MTP40 antigen); Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity; Belongs to the bacterial phospholipase C family. | 0.900 |
impA | plcB | Rv1604 | Rv2350c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Membrane-associated phospholipase C 2 PlcB; Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity. | 0.900 |
impA | plcC | Rv1604 | Rv2349c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Rv2349c, (MT2414, MTCY98.18c), len: 508 aa. Probable plcC, phospolipase C 3 (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C precursor from Pseudomonas aeruginosa (692 aa), FASTA scores: opt: 1013, E(): 9.3e-54, (38.85% identity in 525 aa overlap); P06200|PHLC_PSEAE hemolytic phospholipase C precursor from Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 630, E(): 1.5e-30, (35.15% identity in 535 aa overlap); Q9S816|T12J13.18|T21P5.4 putative phospholipase from Arabidopsis thaliana (Mouse-ear cr [...] | 0.900 |
impA | plcD | Rv1604 | Rv1755c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Rv1755c, (MT1799, MTCY28.21c), len: 280 aa. Probable plcD, phospholipase C 4 (fragment) (see citations below),highly similar to C-terminus of other phospholipases e.g. CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 from Mycobacterium tuberculosis (512 aa), FASTA score: (71.1% identity in 284 aa overlap); etc. Note that this ORF has been interrupted by insertion of IS6110 element. Belongs to the bacterial phospholipase C family. | 0.900 |
impA | suhB | Rv1604 | Rv2701c | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | Inositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol- 6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency. | 0.939 |
ino1 | impA | Rv0046c | Rv1604 | Inositol-3-phosphate synthase; Catalyzes the conversion of glucose 6-phosphate to 1D-myo- inositol 3-phosphate; Belongs to the myo-inositol 1-phosphate synthase family. | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.983 |
ino1 | suhB | Rv0046c | Rv2701c | Inositol-3-phosphate synthase; Catalyzes the conversion of glucose 6-phosphate to 1D-myo- inositol 3-phosphate; Belongs to the myo-inositol 1-phosphate synthase family. | Inositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol- 6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency. | 0.959 |
plcA | impA | Rv2351c | Rv1604 | Membrane-associated phospholipase C 1 PlcA (MTP40 antigen); Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity; Belongs to the bacterial phospholipase C family. | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.900 |