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dapB protein (Mycobacterium tuberculosis H37Rv) - STRING interaction network
"dapB" - Dihydrodipicolinate reductase in Mycobacterium tuberculosis H37Rv
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH (245 aa)    
Predicted Functional Partners:
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (300 aa)
 
 
  0.992
dapD
Transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (317 aa)
 
 
  0.975
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M.tuberculosis in the host (PubMed-12637582) (447 aa)
 
   
  0.921
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (289 aa)
 
   
  0.874
Rv2772c
Transmembrane protein (157 aa)
   
        0.868
Rv2774c
Hypothetical protein (134 aa)
              0.840
aspB
Aspartate aminotransferase (388 aa)
   
 
  0.805
dapC
Aminotransferase; Involved in the lysine biosynthetic pathways. It catalyzes the transfer of an amino group from L-glutamate to N- succinyl-2-l-amino-6-oxoheptanedioate (N-succinyl-2-l-amino-6- ketopimelate) in a PLP-dependent reaction, yielding as products N- succinyl-l-2,6-diaminoheptanedioate (N-succinyl-diaminopimelate) and 2-oxoglutarate (Probable) (397 aa)
   
 
  0.805
aspC
Aminotransferase (429 aa)
   
 
  0.805
ask
Aspartokinase; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine (421 aa)
 
 
  0.797
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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