node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2802c | mazE9 | Rv2802c | Rv2801A | Rv2802c, (MTCY16B7.41), len: 347 aa. Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35% identity in 91 aa overlap); and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa), FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa. This region is a possible MT-complex-specific [...] | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | 0.665 |
Rv2802c | mazF9 | Rv2802c | Rv2801c | Rv2802c, (MTCY16B7.41), len: 347 aa. Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35% identity in 91 aa overlap); and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa), FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa. This region is a possible MT-complex-specific [...] | Toxin MazF9; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene. In E.coli expression with non- cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin. Belongs to the PemK/MazF family. | 0.694 |
mazE3 | mazE6 | Rv1103c | Rv1991A | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.871 |
mazE3 | mazF3 | Rv1103c | Rv1102c | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Toxin MazF3; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases per [...] | 0.960 |
mazE3 | mazF9 | Rv1103c | Rv2801c | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Toxin MazF9; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene. In E.coli expression with non- cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin. Belongs to the PemK/MazF family. | 0.664 |
mazE6 | mazE3 | Rv1991A | Rv1103c | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | 0.871 |
mazE6 | mazE9 | Rv1991A | Rv2801A | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | 0.804 |
mazE6 | mazF2 | Rv1991A | Rv0659c | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Toxin MazF2; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli partially inhibits cell growth after one cell generation. Its cognate antitoxin is MazE2. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.669 |
mazE6 | mazF3 | Rv1991A | Rv1102c | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Toxin MazF3; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases per [...] | 0.782 |
mazE6 | mazF4 | Rv1991A | Rv1495 | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Possible toxin MazF4; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases in the sequence UCGCU. Overexpression in M.smegmatis but not E.coli inhibits growth, this effect is neutralized by coexpression with cognate toxin MazE4. Belongs to the PemK/MazF family. | 0.638 |
mazE6 | mazF5 | Rv1991A | Rv1942c | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Possible toxin MazF5; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE5. Probably an endoribonuclease (By similarity). | 0.656 |
mazE6 | mazF9 | Rv1991A | Rv2801c | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | Toxin MazF9; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene. In E.coli expression with non- cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin. Belongs to the PemK/MazF family. | 0.860 |
mazE7 | mazF3 | Rv2063 | Rv1102c | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | Toxin MazF3; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases per [...] | 0.436 |
mazE7 | mazF4 | Rv2063 | Rv1495 | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | Possible toxin MazF4; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases in the sequence UCGCU. Overexpression in M.smegmatis but not E.coli inhibits growth, this effect is neutralized by coexpression with cognate toxin MazE4. Belongs to the PemK/MazF family. | 0.489 |
mazE7 | mazF9 | Rv2063 | Rv2801c | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | Toxin MazF9; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene. In E.coli expression with non- cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin. Belongs to the PemK/MazF family. | 0.828 |
mazE9 | Rv2802c | Rv2801A | Rv2802c | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | Rv2802c, (MTCY16B7.41), len: 347 aa. Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35% identity in 91 aa overlap); and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa), FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa. This region is a possible MT-complex-specific [...] | 0.665 |
mazE9 | mazE6 | Rv2801A | Rv1991A | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.804 |
mazE9 | mazF2 | Rv2801A | Rv0659c | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | Toxin MazF2; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli partially inhibits cell growth after one cell generation. Its cognate antitoxin is MazE2. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.629 |
mazE9 | mazF3 | Rv2801A | Rv1102c | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | Toxin MazF3; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases per [...] | 0.568 |
mazE9 | mazF5 | Rv2801A | Rv1942c | Possible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9. | Possible toxin MazF5; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE5. Probably an endoribonuclease (By similarity). | 0.803 |