STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vapB23Possible antitoxin VapB23; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC23. (82 aa)    
Predicted Functional Partners:
vapC23
Possible toxin VapC23; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB23 (By similarity). Belongs to the PINc/VapC protein family.
       0.833
vapB28
Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28.
      
 0.751
vapB30
Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30.
      
 0.659
vapB44
Possible antitoxin VapB44; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC44.
      
 0.657
vapB34
Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34.
      
 0.656
vapB45
Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC45.
      
 0.652
vapB41
Possible antitoxin VapB41; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC41.
      
 0.652
vapB19
Possible antitoxin VapB19; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC19.
      
 0.630
Rv2017
Transcriptional regulatory protein; Rv2017, (MTV018.04), len: 346 aa. Transcriptional regulator. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature in C-terminal half, may be fortuitous. Contains probable helix-turn-helix motif at aa 18-39 (Score 2243, +6.83 SD); IPR001387 Helix-turn-helix type 3.
      
 0.549
Rv2862c
Rv2862c, (MTV003.08), len: 194 aa. Conserved hypothetical protein, showing some similarity with others e.g. Q9X8X5|SCH35.31c hypothetical 19.6 KDA protein from Streptomyces coelicolor (180 aa), FASTA scores: opt: 266,E(): 2.2e-11, (34.65% identity in 179 aa overlap); Q9Z5H1|ML0169|MLCB373.19 hypothetical 22.1 KDA protein from Mycobacterium leprae (200 aa), FASTA scores: opt: 195, E(): 2.3e-06, (30.15% identity in 189 aa overlap); etc. Also some similarity to P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 conserved hypothetical protein from Mycobacterium tuberculosis (230 aa), FASTA score [...]
       0.543
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.