node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PPE34 | lppX | Rv1917c | Rv2945c | PPE family protein PPE34; Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL- 4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF- kappa-B signaling pathways. | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | 0.694 |
PPE34 | mmpL7 | Rv1917c | Rv2942 | PPE family protein PPE34; Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL- 4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF- kappa-B signaling pathways. | Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model. | 0.760 |
PPE42 | lppX | Rv2608 | Rv2945c | PPE family protein PPE42; Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response; Belongs to the mycobacterial PPE family. | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | 0.747 |
PPE42 | mmpL7 | Rv2608 | Rv2942 | PPE family protein PPE42; Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response; Belongs to the mycobacterial PPE family. | Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model. | 0.769 |
PPE54 | lppX | Rv3343c | Rv2945c | PPE family protein PPE54; Probably plays a role in host phagosome maturation arrest. | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | 0.704 |
PPE54 | mmpL7 | Rv3343c | Rv2942 | PPE family protein PPE54; Probably plays a role in host phagosome maturation arrest. | Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model. | 0.764 |
PPE8 | lppX | Rv0355c | Rv2945c | PPE family protein PPE8; Rv0355c, (MTCY13E10.15c, MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17,E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; [...] | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | 0.675 |
PPE8 | mmpL7 | Rv0355c | Rv2942 | PPE family protein PPE8; Rv0355c, (MTCY13E10.15c, MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17,E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; [...] | Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model. | 0.758 |
drrC | lppX | Rv2938 | Rv2945c | Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | 0.775 |
drrC | mmpL7 | Rv2938 | Rv2942 | Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model. | 0.782 |
drrC | ppsE | Rv2938 | Rv2935 | Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | Phenolpthiocerol synthesis type-I polyketide synthase PpsE; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. | 0.982 |
fadD28 | mmpL7 | Rv2941 | Rv2942 | Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase Mas for further chain extension. Involved in the biosynthesis of mycoserates. Probably plays a role in host phagosome maturation arrest. Belongs to the ATP-dependent AMP-binding enzyme family. | Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model. | 0.937 |
fadD28 | papA1 | Rv2941 | Rv3824c | Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase Mas for further chain extension. Involved in the biosynthesis of mycoserates. Probably plays a role in host phagosome maturation arrest. Belongs to the ATP-dependent AMP-binding enzyme family. | Conserved polyketide synthase associated protein PapA1; Catalyzes the acylation of trehalose-2-sulfate-2'-palmitate (SL659) by adding the (hydroxy)phthioceranoyl group at the 3'-position to yield the diacylated intermediate 2-palmitoyl-3-(C43)-phthioceranyl- alpha, alpha'-D-trehalose-2'-sulfate (SL1278) during the cell wall sulfolipid-1 (SL-1) biosynthesis; Belongs to the PapA acyltransferase family. | 0.489 |
fadD28 | papA2 | Rv2941 | Rv3820c | Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase Mas for further chain extension. Involved in the biosynthesis of mycoserates. Probably plays a role in host phagosome maturation arrest. Belongs to the ATP-dependent AMP-binding enzyme family. | Possible conserved polyketide synthase associated protein PapA2; Catalyzes the acylation of trehalose-2-sulfate by adding the palmitoyl group at the 2'-position to yield the intermediate trehalose- 2-sulfate-2'-palmitate (SL659) during the cell wall sulfolipid-1 (SL-1) biosynthesis; Belongs to the PapA acyltransferase family. | 0.559 |
fadD28 | ppsE | Rv2941 | Rv2935 | Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase Mas for further chain extension. Involved in the biosynthesis of mycoserates. Probably plays a role in host phagosome maturation arrest. Belongs to the ATP-dependent AMP-binding enzyme family. | Phenolpthiocerol synthesis type-I polyketide synthase PpsE; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. | 0.866 |
lppX | PPE34 | Rv2945c | Rv1917c | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | PPE family protein PPE34; Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL- 4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF- kappa-B signaling pathways. | 0.694 |
lppX | PPE42 | Rv2945c | Rv2608 | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | PPE family protein PPE42; Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response; Belongs to the mycobacterial PPE family. | 0.747 |
lppX | PPE54 | Rv2945c | Rv3343c | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | PPE family protein PPE54; Probably plays a role in host phagosome maturation arrest. | 0.704 |
lppX | PPE8 | Rv2945c | Rv0355c | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | PPE family protein PPE8; Rv0355c, (MTCY13E10.15c, MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17,E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; [...] | 0.675 |
lppX | drrC | Rv2945c | Rv2938 | Probable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs to the LppX/LprAFG lipoprotein family. | Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. | 0.775 |