Probable polyketide synthase Pks1; May play a role in phthiocerol biosynthesis.

19 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family.

Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable).

Rv0583c, (MTV039.21c), len: 228 aa. Probable lpqN,conserved lipoprotein, equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa), FASTA scores: opt: 945, E(): 0, (62.7% identity in 228 aa overlap); and similar to others from Mycobacteria e.g. Rv0040c and Rv1016c from Mycobacterium tuberculosis. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.

Possible conserved polyketide synthase associated protein PapA5; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Is also able to catalyze acyl transfer using various nucleophiles as acceptors and several acyl-CoA thioesters as donors in vitro; preference is observed for saturated medium chain alcohols and long [...]

Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family.

PPE family protein PPE42; Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response; Belongs to the mycobacterial PPE family.

P-hydroxybenzoyl-AMP ligase FadD22; Catalyzes the adenylation of p-hydroxybenzoic acid (pHBA) to form p-hydroxybenzoic acid-AMP (pHBA-AMP), which is converted directly to p-hydroxybenzoyl-S-FadD22 (pHBA-S-FAdD22) thioester intermediate in a CoA-independent manner by attack of the phosphopantetheine thiol of FadD22. Usually, this intermediate primes the biosynthesis of the phenolphthiocerol (PPOL) by presenting the pHBA starter unit for elongation by Pks15/1, but M.tuberculosis lacks Pks15/1 due to a natural frameshift and thus is unable to produce PPOL. Belongs to the ATP-dependent AMP [...]

Rv0878c, (MTCY31.06c), len: 443 aa. PPE13, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: 1044, E(): 0, (47.4% identity in 397 aa overlap); MTV014_3,MTCI65_2, MTCY98_24, MTCY3C7_23, MTCY48_17, MTV004_5,MTV004_3, etc. Predicted to be an outer membrane protein (See Song et al., 2008).