node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0121c | Rv1155 | Rv0121c | Rv1155 | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | 0.894 |
Rv0121c | Rv1875 | Rv0121c | Rv1875 | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap). | 0.940 |
Rv0121c | Rv2991 | Rv0121c | Rv2991 | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | 0.908 |
Rv0121c | Rv3369 | Rv0121c | Rv3369 | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | Conserved protein; Rv3369, (MTV004.27), len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa),FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap). | 0.893 |
Rv1155 | Rv0121c | Rv1155 | Rv0121c | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | 0.894 |
Rv1155 | Rv1558 | Rv1155 | Rv1558 | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Conserved protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr- mediated F420H(2) oxidation is therefore li [...] | 0.821 |
Rv1155 | Rv1875 | Rv1155 | Rv1875 | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap). | 0.919 |
Rv1155 | Rv2991 | Rv1155 | Rv2991 | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | 0.895 |
Rv1155 | Rv3178 | Rv1155 | Rv3178 | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Conserved hypothetical protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. Since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in t [...] | 0.740 |
Rv1155 | Rv3369 | Rv1155 | Rv3369 | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Conserved protein; Rv3369, (MTV004.27), len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa),FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap). | 0.846 |
Rv1155 | ddn | Rv1155 | Rv3547 | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | Deazaflavin-dependent nitroreductase Ddn; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of both benzoquinone and naphthoquinone analogs; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fq [...] | 0.797 |
Rv1558 | Rv1155 | Rv1558 | Rv1155 | Conserved protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr- mediated F420H(2) oxidation is therefore li [...] | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | 0.821 |
Rv1558 | Rv2991 | Rv1558 | Rv2991 | Conserved protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr- mediated F420H(2) oxidation is therefore li [...] | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | 0.701 |
Rv1875 | Rv0121c | Rv1875 | Rv0121c | Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap). | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | 0.940 |
Rv1875 | Rv1155 | Rv1875 | Rv1155 | Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap). | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | 0.919 |
Rv1875 | Rv2991 | Rv1875 | Rv2991 | Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap). | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | 0.803 |
Rv1875 | Rv3369 | Rv1875 | Rv3369 | Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap). | Conserved protein; Rv3369, (MTV004.27), len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa),FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap). | 0.839 |
Rv2991 | Rv0121c | Rv2991 | Rv0121c | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | Conserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc. | 0.908 |
Rv2991 | Rv1155 | Rv2991 | Rv1155 | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 o [...] | 0.895 |
Rv2991 | Rv1558 | Rv2991 | Rv1558 | Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa), FASTA scores: opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06 [...] | Conserved protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr- mediated F420H(2) oxidation is therefore li [...] | 0.701 |